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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2736
Preferred Name Metabotropic glutamate receptor 4
Synonyms GPRC1D | GRM4 | MGLUR4 | Metabotropic glutamate receptor 4 | mGluR4
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family c g protein-coupled receptor > small molecule receptor (family c gpcr) > neurotransmitter receptor (family c gpcr) > metabotropic glutamate receptor

Target Components

Component Description Relationship Accession
Metabotropic glutamate receptor 4 SINGLE PROTEIN Q14833

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000124493
Ensembl ENSG00000124493
GO Cellular Component GO:0005622 (intracellular)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031410 (cytoplasmic vesicle)
GO:0042734 (presynaptic membrane)
GO Molecular Function GO:0001642 (group III metabotropic glutamate receptor activity)
GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0008066 (glutamate receptor activity)
GO Biological Process GO:0000187 (activation of MAPK activity)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007196 (adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway)
GO:0007268 (chemical synaptic transmission)
GO:0007269 (neurotransmitter secretion)
GO:0043410 (positive regulation of MAPK cascade)
GO:0043523 (regulation of neuron apoptotic process)
GO:0051966 (regulation of synaptic transmission, glutamatergic)
Wikipedia Metabotropic_glutamate_receptor_4

Target Cross References - Protein

canSAR Q14833
Human Protein Atlas ENSG00000124493
Guide to Pharmacology 292
Open Targets ENSG00000124493
PharmGKB PA28993
Pharos Q14833 (Tchem)
Reactome R-HSA-418594 (G alpha (i) signalling events.)
R-HSA-420499 (Class C/3 (Metabotropic glutamate/pheromone receptors).)
UniProt B3KVL9 B7Z1T9 B7Z1U6 F5GXM5 Q14833 Q5SZ84 Q6ZMQ2

Target Cross References - Domain

InterPro IPR000162 (GPCR_3_mtglu_rcpt.)
IPR000337 (GPCR_3.)
IPR001786 (GPCR_3_mtglu_rcpt_4.)
IPR001828 (ANF_lig-bd_rcpt.)
IPR011500 (GPCR_3_9-Cys_dom.)
IPR017978 (GPCR_3_C.)
IPR017979 (GPCR_3_CS.)
IPR028082 (Peripla_BP_I.)
Pfam PF00003 (7tm_3)
PF01094 (ANF_receptor)
PF07562 (NCD3G)