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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2735
Preferred Name DNA polymerase delta subunit 1
Synonyms DNA polymerase delta catalytic subunit | DNA polymerase subunit delta p125 | POLD | POLD1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > transferase

Target Components

Component Description Relationship Accession
DNA polymerase delta catalytic subunit SINGLE PROTEIN P28340

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2363042 DNA polymerase (alpha/delta/epsilon) PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000062822
Ensembl ENSG00000062822
GO Cellular Component GO:0000109 (nucleotide-excision repair complex)
GO:0000784 (nuclear chromosome, telomeric region)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0016020 (membrane)
GO:0016235 (aggresome)
GO:0043625 (delta DNA polymerase complex)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003676 (nucleic acid binding)
GO:0003677 (DNA binding)
GO:0003682 (chromatin binding)
GO:0003684 (damaged DNA binding)
GO:0003887 (DNA-directed DNA polymerase activity)
GO:0004518 (nuclease activity)
GO:0004527 (exonuclease activity)
GO:0005515 (protein binding)
GO:0008296 (3'-5'-exodeoxyribonuclease activity)
GO:0008408 (3'-5' exonuclease activity)
GO:0016740 (transferase activity)
GO:0016779 (nucleotidyltransferase activity)
GO:0016787 (hydrolase activity)
GO:0019899 (enzyme binding)
GO:0046872 (metal ion binding)
GO:0051536 (iron-sulfur cluster binding)
GO:0051539 (4 iron, 4 sulfur cluster binding)
GO Biological Process GO:0000722 (telomere maintenance via recombination)
GO:0000723 (telomere maintenance)
GO:0000731 (DNA synthesis involved in DNA repair)
GO:0006260 (DNA replication)
GO:0006261 (DNA-dependent DNA replication)
GO:0006271 (DNA strand elongation involved in DNA replication)
GO:0006281 (DNA repair)
GO:0006283 (transcription-coupled nucleotide-excision repair)
GO:0006287 (base-excision repair, gap-filling)
GO:0006296 (nucleotide-excision repair, DNA incision, 5'-to lesion)
GO:0006297 (nucleotide-excision repair, DNA gap filling)
GO:0006298 (mismatch repair)
GO:0009411 (response to UV)
GO:0019985 (translesion synthesis)
GO:0033683 (nucleotide-excision repair, DNA incision)
GO:0034644 (cellular response to UV)
GO:0042769 (DNA damage response, detection of DNA damage)
GO:0045004 (DNA replication proofreading)
GO:0055089 (fatty acid homeostasis)
GO:0071897 (DNA biosynthetic process)
GO:0090305 (nucleic acid phosphodiester bond hydrolysis)
Wikipedia POLD1

Target Cross References - Protein

canSAR P28340
CGD Colorectal cancer, susceptibility to, 10
Human Protein Atlas ENSG00000062822
IntAct P28340
Open Targets ENSG00000062822
PharmGKB PA33496
Reactome R-HSA-110314 (Recognition of DNA damage by PCNA-containing replication complex.)
R-HSA-174411 (Polymerase switching on the C-strand of the telomere.)
R-HSA-174414 (Processive synthesis on the C-strand of the telomere.)
R-HSA-174417 (Telomere C-strand (Lagging Strand) Synthesis.)
R-HSA-174437 (Removal of the Flap Intermediate from the C-strand.)
R-HSA-2564830 (Cytosolic iron-sulfur cluster assembly.)
R-HSA-5358565 (Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha).)
R-HSA-5358606 (Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta).)
R-HSA-5651801 (PCNA-Dependent Long Patch Base Excision Repair.)
R-HSA-5656169 (Termination of translesion DNA synthesis.)
R-HSA-5685942 (HDR through Homologous Recombination (HRR).)
R-HSA-5696397 (Gap-filling DNA repair synthesis and ligation in GG-NER.)
R-HSA-5696400 (Dual Incision in GG-NER.)
R-HSA-6782135 (Dual incision in TC-NER.)
R-HSA-6782210 (Gap-filling DNA repair synthesis and ligation in TC-NER.)
R-HSA-69091 (Polymerase switching.)
R-HSA-69166 (Removal of the Flap Intermediate.)
R-HSA-69183 (Processive synthesis on the lagging strand.)
UniProt P28340 Q8NER3 Q96H98

Target Cross References - Domain

InterPro IPR006133 (DNA-dir_DNA_pol_B_exonuc.)
IPR006134 (DNA-dir_DNA_pol_B_multi_dom.)
IPR006172 (DNA-dir_DNA_pol_B.)
IPR012337 (RNaseH-like_dom.)
IPR017964 (DNA-dir_DNA_pol_B_CS.)
IPR023211 (DNA_pol_palm_dom.)
IPR025687 (Znf-C4pol.)
Pfam PF00136 (DNA_pol_B)
PF03104 (DNA_pol_B_exo1)
PF14260 (zf-C4pol)