ChEMBL logo


ChEMBL Statistics
  Loading Statistics...

Target Report Card

Target Name and Classification

Target ID CHEMBL2732
Preferred Name DNA polymerase gamma subunit 1
Synonyms DNA polymerase subunit gamma-1 | MDP1 | Mitochondrial DNA polymerase catalytic subunit | POLG | POLG1 | POLGA | PolG-alpha
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
DNA polymerase subunit gamma-1 SINGLE PROTEIN P54098

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000140521
Ensembl ENSG00000140521
GO Cellular Component GO:0005739 (mitochondrion)
GO:0005760 (gamma DNA polymerase complex)
GO:0042645 (mitochondrial nucleoid)
GO:0043195 (terminal bouton)
GO:0043234 (protein complex)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0002020 (protease binding)
GO:0003676 (nucleic acid binding)
GO:0003677 (DNA binding)
GO:0003682 (chromatin binding)
GO:0003887 (DNA-directed DNA polymerase activity)
GO:0005515 (protein binding)
GO:0008408 (3'-5' exonuclease activity)
GO:0016740 (transferase activity)
GO:0016779 (nucleotidyltransferase activity)
GO Biological Process GO:0006259 (DNA metabolic process)
GO:0006260 (DNA replication)
GO:0006261 (DNA-dependent DNA replication)
GO:0006264 (mitochondrial DNA replication)
GO:0006287 (base-excision repair, gap-filling)
GO:0007568 (aging)
GO:0009416 (response to light stimulus)
GO:0010332 (response to gamma radiation)
GO:0055093 (response to hyperoxia)
GO:0071333 (cellular response to glucose stimulus)
GO:0071897 (DNA biosynthetic process)
GO:0090305 (nucleic acid phosphodiester bond hydrolysis)
Wikipedia POLG

Target Cross References - Protein

canSAR P54098
CGD Progressive external ophthalmoplegia, autosomal dominant; Progressive external ophthalmoplegia, autosomal recessive; Mitochondrial DNA depletion syndrome 4B; Sensory ataxia, dysarthria, and ophthalmoparesis; Mitochondrial DNA depletion syndrome 4A (Alpers type); Alpers syndrome; POLG-related ataxia neuropathy spectrum disorders
Human Protein Atlas ENSG00000140521
IntAct P54098
Open Targets ENSG00000140521
PharmGKB PA33500
UniProt P54098 Q8NFM2 Q92515

Target Cross References - Domain

InterPro IPR001098 (DNA-dir_DNA_pol_A_palm_dom.)
IPR002297 (DNA-dir_DNA_pol_A_mt.)
IPR012337 (RNaseH-like_dom.)
IPR019760 (DNA-dir_DNA_pol_A_CS.)
Pfam PF00476 (DNA_pol_A)

Target Cross References - Structure

PDBe 3IKM 4ZTU 4ZTZ 5C51 5C52 5C53
CREDO 3IKM 4ZTU 4ZTZ 5C51 5C52 5C53