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Target Report Card

Target Name and Classification

Target ID CHEMBL2730
Preferred Name Protein-glutamine gamma-glutamyltransferase
Synonyms Protein-glutamine gamma-glutamyltransferase 2 | TG(C) | TGC | TGM2 | TGase C | TGase H | TGase-2 | Tissue transglutaminase | Transglutaminase C | Transglutaminase H | Transglutaminase-2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Protein-glutamine gamma-glutamyltransferase 2 SINGLE PROTEIN P21980

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000198959
Ensembl ENSG00000198959
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005783 (endoplasmic reticulum)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005925 (focal adhesion)
GO:0031012 (extracellular matrix)
GO:0031226 (intrinsic component of plasma membrane)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0003810 (protein-glutamine gamma-glutamyltransferase activity)
GO:0005515 (protein binding)
GO:0005525 (GTP binding)
GO:0016740 (transferase activity)
GO:0016746 (transferase activity, transferring acyl groups)
GO:0019904 (protein domain specific binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0001974 (blood vessel remodeling)
GO:0007200 (phospholipase C-activating G-protein coupled receptor signaling pathway)
GO:0018149 (peptide cross-linking)
GO:0018153 (isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine)
GO:0032471 (negative regulation of endoplasmic reticulum calcium ion concentration)
GO:0043065 (positive regulation of apoptotic process)
GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB signaling)
GO:0043277 (apoptotic cell clearance)
GO:0045785 (positive regulation of cell adhesion)
GO:0048661 (positive regulation of smooth muscle cell proliferation)
GO:0050729 (positive regulation of inflammatory response)
GO:0051260 (protein homooligomerization)
GO:0051482 (positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway)
GO:0051561 (positive regulation of mitochondrial calcium ion concentration)
GO:0060445 (branching involved in salivary gland morphogenesis)
GO:0060662 (salivary gland cavitation)
Wikipedia Tissue_transglutaminase

Target Cross References - Protein

canSAR P21980
Human Protein Atlas ENSG00000198959
IntAct P21980
Open Targets ENSG00000198959
PharmGKB PA36491
UniProt E1P5V9 P21980 Q16436 Q6B838 Q9BTN7 Q9H035 Q9UH35

Target Cross References - Domain

InterPro IPR001102 (Transglutaminase_N.)
IPR002931 (Transglutaminase-like.)
IPR008958 (Transglutaminase_C.)
IPR013783 (Ig-like_fold.)
IPR013808 (Transglutaminase_AS.)
IPR014756 (Ig_E-set.)
IPR023608 (Transglutaminase_animal.)
IPR036238 (Transglutaminase_C_sf.)
IPR036985 (Transglutaminase-like_sf.)
Pfam PF00868 (Transglut_N)
PF00927 (Transglut_C)
PF01841 (Transglut_core)

Target Cross References - Structure

PDBe 1KV3 2Q3Z 3LY6 3S3J 3S3P 3S3S 4PYG
CREDO 1KV3 2Q3Z 3LY6 3S3J 3S3P 3S3S 4PYG