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Target Report Card

Target Name and Classification

Target ID CHEMBL2722
Target Type SINGLE PROTEIN
Preferred Name Cytochrome P450 11B2
Synonyms ALDOS | Aldosterone synthase | Aldosterone-synthesizing enzyme | CYP11B2 | CYPXIB2 | Cytochrome P-450Aldo | Cytochrome P-450C18 | Cytochrome P450 11B2, mitochondrial | Steroid 18-hydroxylase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > cytochrome p450 > cytochrome p450 family 11 > cytochrome p450 family 11b > cytochrome p450 11b2

Target Components

Component Description Relationship Accession
Cytochrome P450 11B2, mitochondrial SINGLE PROTEIN P19099

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000179142
Ensembl ENSG00000179142
GO Cellular Component GO:0005739 (mitochondrion)
GO:0005743 (mitochondrial inner membrane)
GO:0016020 (membrane)
GO:0031966 (mitochondrial membrane)
GO Molecular Function GO:0004497 (monooxygenase activity)
GO:0004507 (steroid 11-beta-monooxygenase activity)
GO:0005506 (iron ion binding)
GO:0008395 (steroid hydroxylase activity)
GO:0016491 (oxidoreductase activity)
GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)
GO:0016709 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen)
GO:0020037 (heme binding)
GO:0046872 (metal ion binding)
GO:0047783 (corticosterone 18-monooxygenase activity)
GO Biological Process GO:0002017 (regulation of blood volume by renal aldosterone)
GO:0003091 (renal water homeostasis)
GO:0006629 (lipid metabolic process)
GO:0006694 (steroid biosynthetic process)
GO:0006700 (C21-steroid hormone biosynthetic process)
GO:0006705 (mineralocorticoid biosynthetic process)
GO:0008202 (steroid metabolic process)
GO:0008203 (cholesterol metabolic process)
GO:0016125 (sterol metabolic process)
GO:0032342 (aldosterone biosynthetic process)
GO:0032870 (cellular response to hormone stimulus)
GO:0034651 (cortisol biosynthetic process)
GO:0035865 (cellular response to potassium ion)
GO:0044550 (secondary metabolite biosynthetic process)
GO:0055075 (potassium ion homeostasis)
GO:0055078 (sodium ion homeostasis)
GO:0055114 (oxidation-reduction process)
GO:0071375 (cellular response to peptide hormone stimulus)
Wikipedia Aldosterone_synthase

Target Cross References - Protein

canSAR P19099
CGD Corticosterone methyloxidase type I deficiency; Corticosterone methyloxidase type II deficiency; Glucocorticoid-remediable aldosteronism
Human Protein Atlas ENSG00000179142
Guide to Pharmacology 1360
Open Targets ENSG00000179142
PharmGKB PA134
Reactome R-HSA-193993 (Mineralocorticoid biosynthesis.)
R-HSA-194002 (Glucocorticoid biosynthesis.)
R-HSA-211976 (Endogenous sterols.)
UniProt B0ZBE4 P19099 Q16726

Target Cross References - Domain

InterPro IPR001128 (Cyt_P450.)
IPR002399 (Cyt_P450_mitochondrial.)
IPR017972 (Cyt_P450_CS.)
Pfam PF00067 (p450)

Target Cross References - Structure

PDBe 4DVQ 4FDH 4ZGX
CREDO 4DVQ 4FDH 4ZGX
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