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Target Report Card

Target Name and Classification

Target ID CHEMBL2721
Preferred Name Excitatory amino acid transporter 3
Synonyms EAAC1 | EAAT3 | Excitatory amino acid transporter 3 | Excitatory amino-acid carrier 1 | Neuronal and epithelial glutamate transporter | SLC1A1 | Sodium-dependent glutamate/aspartate transporter 3 | Solute carrier family 1 member 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > electrochemical transporter > slc superfamily of solute carriers > slc01 family of amino acid transporters

Target Components

Component Description Relationship Accession
Excitatory amino acid transporter 3 SINGLE PROTEIN P43005

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000106688
Ensembl ENSG00000106688
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016324 (apical plasma membrane)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0005313 (L-glutamate transmembrane transporter activity)
GO:0005314 (high-affinity glutamate transmembrane transporter activity)
GO:0005515 (protein binding)
GO:0015171 (amino acid transmembrane transporter activity)
GO:0015293 (symporter activity)
GO:0015501 (glutamate:sodium symporter activity)
GO:0016595 (glutamate binding)
GO:0033229 (cysteine transmembrane transporter activity)
GO Biological Process GO:0006810 (transport)
GO:0006811 (ion transport)
GO:0007268 (chemical synaptic transmission)
GO:0010460 (positive regulation of heart rate)
GO:0014047 (glutamate secretion)
GO:0015813 (L-glutamate transport)
GO:0042883 (cysteine transport)
GO:0051260 (protein homooligomerization)
GO:0051938 (L-glutamate import)
GO:0070779 (D-aspartate import)
GO:0089711 (L-glutamate transmembrane transport)
GO:1903712 (cysteine transmembrane transport)
Wikipedia SLC1A1

Target Cross References - Protein

canSAR P43005
CGD Schizophrenia
Human Protein Atlas ENSG00000106688
IntAct P43005
Guide to Pharmacology 870
Open Targets ENSG00000106688
PharmGKB PA35826
Reactome R-HSA-210500 (Glutamate Neurotransmitter Release Cycle.)
R-HSA-425393 (Transport of inorganic cations/anions and amino acids/oligopeptides.)
UniProt O75587 P43005 Q5VZ24 Q8N199 Q9UEW2

Target Cross References - Domain

InterPro IPR001991 (Na-dicarboxylate_symporter.)
IPR018107 (Na-dicarboxylate_symporter_CS.)
Pfam PF00375 (SDF)