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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL272
Target Type SINGLE PROTEIN
Preferred Name Protein farnesyltransferase beta subunit
Synonyms CAAX farnesyltransferase subunit beta | FNTB | FTase-beta | Protein farnesyltransferase subunit beta | Ras proteins prenyltransferase subunit beta
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Protein farnesyltransferase subunit beta SINGLE PROTEIN P49356

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2094108 Protein farnesyltransferase PROTEIN COMPLEX
CHEMBL2096991 Protein farnesyl/geranylgeranyl transferase PROTEIN COMPLEX GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000257365
Ensembl ENSG00000257365
GO Cellular Component GO:0005829 (cytosol)
GO:0005875 (microtubule associated complex)
GO:0005965 (protein farnesyltransferase complex)
GO:0043234 (protein complex)
GO Molecular Function GO:0003824 (catalytic activity)
GO:0004311 (farnesyltranstransferase activity)
GO:0004659 (prenyltransferase activity)
GO:0004660 (protein farnesyltransferase activity)
GO:0005515 (protein binding)
GO:0008144 (drug binding)
GO:0008270 (zinc ion binding)
GO:0016740 (transferase activity)
GO:0019840 (isoprenoid binding)
GO:0042277 (peptide binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0008284 (positive regulation of cell proliferation)
GO:0008285 (negative regulation of cell proliferation)
GO:0010035 (response to inorganic substance)
GO:0014070 (response to organic cyclic compound)
GO:0018343 (protein farnesylation)
GO:0022400 (regulation of rhodopsin mediated signaling pathway)
GO:0034097 (response to cytokine)
GO:0042060 (wound healing)
GO:0042127 (regulation of cell proliferation)
GO:0045787 (positive regulation of cell cycle)
GO:0048146 (positive regulation of fibroblast proliferation)
GO:0051770 (positive regulation of nitric-oxide synthase biosynthetic process)
Wikipedia FNTB

Target Cross References - Protein

canSAR P49356
Human Protein Atlas ENSG00000257365
IntAct P49356
Guide to Pharmacology 2826
Open Targets ENSG00000257365
PharmGKB PA28202
Reactome R-HSA-2514859 (Inactivation, recovery and regulation of the phototransduction cascade.)
UniProt B2RDX6 B4E1A0 P49356

Target Cross References - Domain

InterPro IPR001330 (PFTB_repeat.)
IPR008930 (Terpenoid_cyclase/PrenylTrfase.)
IPR026872 (FTB.)
Pfam PF00432 (Prenyltrans)

Target Cross References - Structure

PDBe 1JCQ 1LD7 1LD8 1MZC 1S63 1SA4 1TN6 2F0Y 2H6F 2H6G 2H6H 2H6I 2IEJ 3E37
CREDO 1JCQ 1LD7 1LD8 1MZC 1S63 1SA4 1TN6 2F0Y 2H6F 2H6G 2H6H 2H6I 2IEJ 3E37
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