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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2719
Target Type SINGLE PROTEIN
Preferred Name Calnexin
Synonyms CANX | Calnexin | IP90 | Major histocompatibility complex class I antigen-binding protein p88 | p90
Organism Homo sapiens
Species Group No
Protein Target Classification
  • other cytosolic protein

Target Components

Component Description Relationship Accession
Calnexin SINGLE PROTEIN P27824

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000127022
Ensembl ENSG00000127022
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005783 (endoplasmic reticulum)
GO:0005788 (endoplasmic reticulum lumen)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005790 (smooth endoplasmic reticulum)
GO:0005791 (rough endoplasmic reticulum)
GO:0005829 (cytosol)
GO:0005840 (ribosome)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030424 (axon)
GO:0031012 (extracellular matrix)
GO:0032839 (dendrite cytoplasm)
GO:0042470 (melanosome)
GO:0043025 (neuronal cell body)
GO:0043197 (dendritic spine)
GO:0043209 (myelin sheath)
GO:0043234 (protein complex)
GO:0044233 (ER-mitochondrion membrane contact site)
GO:0070062 (extracellular exosome)
GO:0071556 (integral component of lumenal side of endoplasmic reticulum membrane)
GO Molecular Function GO:0001948 (glycoprotein binding)
GO:0005509 (calcium ion binding)
GO:0005515 (protein binding)
GO:0030246 (carbohydrate binding)
GO:0034185 (apolipoprotein binding)
GO:0035255 (ionotropic glutamate receptor binding)
GO:0044822 (poly(A) RNA binding)
GO:0046872 (metal ion binding)
GO:0051082 (unfolded protein binding)
GO Biological Process GO:0002474 (antigen processing and presentation of peptide antigen via MHC class I)
GO:0006457 (protein folding)
GO:0007568 (aging)
GO:0009306 (protein secretion)
GO:0019886 (antigen processing and presentation of exogenous peptide antigen via MHC class II)
GO:0034975 (protein folding in endoplasmic reticulum)
GO:0048488 (synaptic vesicle endocytosis)
GO:0061077 (chaperone-mediated protein folding)
GO:0072583 (clathrin-mediated endocytosis)
Wikipedia Calnexin

Target Cross References - Protein

canSAR P27824
Human Protein Atlas ENSG00000127022
IntAct P27824
Open Targets ENSG00000127022
PharmGKB PA26055
Reactome R-HSA-168316 (Assembly of Viral Components at the Budding Site.)
R-HSA-2132295 (MHC class II antigen presentation.)
R-HSA-901042 (Calnexin/calreticulin cycle.)
R-HSA-983170 (Antigen Presentation: Folding, assembly and peptide loading of class I MHC.)
UniProt B2R5V8 B4DGP8 B4E2T8 D3DWQ3 D6R9K3 P27824

Target Cross References - Domain

InterPro IPR001580 (Calret/calnex.)
IPR009033 (Calreticulin/calnexin_P_dom.)
IPR013320 (ConA-like_dom.)
IPR018124 (Calret/calnex_CS.)
Pfam PF00262 (Calreticulin)
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