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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2716
Target Type SINGLE PROTEIN
Preferred Name Histone deacetylase 7
Synonyms HD7 | HD7a | HDAC7 | HDAC7A | Histone deacetylase 7 | Histone deacetylase 7A
Organism Homo sapiens
Species Group No
Protein Target Classification
  • epigenetic regulator > eraser > histone deacetylase > hdac class iia

Target Components

Component Description Relationship Accession
Histone deacetylase 7 SINGLE PROTEIN Q8WUI4

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2093865 Histone deacetylase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000061273
Ensembl ENSG00000061273
GO Cellular Component GO:0000118 (histone deacetylase complex)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO Molecular Function GO:0003682 (chromatin binding)
GO:0003714 (transcription corepressor activity)
GO:0004407 (histone deacetylase activity)
GO:0005080 (protein kinase C binding)
GO:0005515 (protein binding)
GO:0016787 (hydrolase activity)
GO:0019789 (SUMO transferase activity)
GO:0019901 (protein kinase binding)
GO:0032041 (NAD-dependent histone deacetylase activity (H3-K14 specific))
GO:0033613 (activating transcription factor binding)
GO:0046872 (metal ion binding)
GO:0070491 (repressing transcription factor binding)
GO:0071889 (14-3-3 protein binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0001570 (vasculogenesis)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0007043 (cell-cell junction assembly)
GO:0016568 (chromatin modification)
GO:0016575 (histone deacetylation)
GO:0016925 (protein sumoylation)
GO:0030182 (neuron differentiation)
GO:0032703 (negative regulation of interleukin-2 production)
GO:0045668 (negative regulation of osteoblast differentiation)
GO:0045892 (negative regulation of transcription, DNA-templated)
GO:0051402 (neuron apoptotic process)
GO:0070932 (histone H3 deacetylation)
GO:0071260 (cellular response to mechanical stimulus)
GO:0090050 (positive regulation of cell migration involved in sprouting angiogenesis)
GO:1901215 (negative regulation of neuron death)
GO:1901223 (negative regulation of NIK/NF-kappaB signaling)
Wikipedia HDAC7

Target Cross References - Protein

canSAR Q8WUI4
Human Protein Atlas ENSG00000061273
IntAct Q8WUI4
Guide to Pharmacology 2661
Open Targets ENSG00000061273
PharmGKB PA162390579
Reactome R-HSA-2122947 (NOTCH1 Intracellular Domain Regulates Transcription.)
R-HSA-2644606 (Constitutive Signaling by NOTCH1 PEST Domain Mutants.)
R-HSA-2894862 (Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.)
R-HSA-3108214 (SUMOylation of DNA damage response and repair proteins.)
UniProt B3KY08 B4DWI0 B4E0Q5 Q6P1W9 Q6W9G7 Q7Z4K2 Q7Z5I1 Q8WUI4 Q96K01 Q9BR73 Q9H7L0 Q9NW41 Q9NWA9 Q9NYK9 Q9UFU7

Target Cross References - Domain

InterPro IPR000286 (His_deacetylse.)
IPR017320 (Histone_deAcase_II_euk.)
IPR023801 (His_deacetylse_dom.)
Pfam PF00850 (Hist_deacetyl)

Target Cross References - Structure

PDBe 3C0Y 3C0Z 3C10 3ZNR 3ZNS
CREDO 3C0Y 3C0Z 3C10 3ZNR 3ZNS
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