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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2709
Target Type SINGLE PROTEIN
Preferred Name Hexokinase type III
Synonyms HK III | HK3 | Hexokinase type III | Hexokinase-3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Hexokinase-3 SINGLE PROTEIN P52790

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000160883
Ensembl ENSG00000160883
GO Cellular Component GO:0005739 (mitochondrion)
GO:0005829 (cytosol)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003824 (catalytic activity)
GO:0004340 (glucokinase activity)
GO:0004396 (hexokinase activity)
GO:0005524 (ATP binding)
GO:0005536 (glucose binding)
GO:0008865 (fructokinase activity)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0016773 (phosphotransferase activity, alcohol group as acceptor)
GO:0019158 (mannokinase activity)
GO Biological Process GO:0001678 (cellular glucose homeostasis)
GO:0005975 (carbohydrate metabolic process)
GO:0006096 (glycolytic process)
GO:0008152 (metabolic process)
GO:0015758 (glucose transport)
GO:0016310 (phosphorylation)
GO:0019318 (hexose metabolic process)
GO:0046835 (carbohydrate phosphorylation)
GO:0051156 (glucose 6-phosphate metabolic process)
GO:0061621 (canonical glycolysis)
Wikipedia HK3

Target Cross References - Protein

canSAR P52790
Human Protein Atlas ENSG00000160883
IntAct P52790
Open Targets ENSG00000160883
PharmGKB PA29303
Reactome R-HSA-70153 (Glucose transport.)
R-HSA-70171 (Glycolysis.)
UniProt P52790 Q8N1E7

Target Cross References - Domain

InterPro IPR001312 (Hexokinase.)
IPR019807 (Hexokinase_BS.)
IPR022672 (Hexokinase_N.)
IPR022673 (Hexokinase_C.)
Pfam PF00349 (Hexokinase_1)
PF03727 (Hexokinase_2)

Target Cross References - Structure

PDBe 3HM8
CREDO 3HM8
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