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Target Report Card

Target Name and Classification

Target ID CHEMBL2706
Preferred Name Receptor-type tyrosine-protein phosphatase beta
Synonyms PTPB | PTPRB | Protein-tyrosine phosphatase beta | R-PTP-beta | Receptor-type tyrosine-protein phosphatase beta | VE-PTP | Vascular endothelial protein tyrosine phosphatase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > phosphatase > protein phosphatase > tyrosine protein phosphatase > receptor tyrosine-protein phosphatase

Target Components

Component Description Relationship Accession
Receptor-type tyrosine-protein phosphatase beta SINGLE PROTEIN P23467

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000127329
Ensembl ENSG00000127329
GO Cellular Component GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0043235 (receptor complex)
GO Molecular Function GO:0004721 (phosphoprotein phosphatase activity)
GO:0004725 (protein tyrosine phosphatase activity)
GO:0005001 (transmembrane receptor protein tyrosine phosphatase activity)
GO:0005515 (protein binding)
GO:0016787 (hydrolase activity)
GO:0016791 (phosphatase activity)
GO Biological Process GO:0001525 (angiogenesis)
GO:0006470 (protein dephosphorylation)
GO:0006796 (phosphate-containing compound metabolic process)
GO:0016311 (dephosphorylation)
GO:0035335 (peptidyl-tyrosine dephosphorylation)
Wikipedia PTPRB

Target Cross References - Protein

Human Protein Atlas ENSG00000127329
IntAct P23467
Guide to Pharmacology 1851
Open Targets ENSG00000127329
PharmGKB PA34010
UniProt B7ZKS8 B7ZKT0 C9JX87 F5H3G6 P23467 Q14D85 Q3MIV7

Target Cross References - Domain

InterPro IPR000242 (PTPase_domain.)
IPR003595 (Tyr_Pase_cat.)
IPR003961 (FN3_dom.)
IPR013783 (Ig-like_fold.)
IPR016130 (Tyr_Pase_AS.)
IPR029021 (Prot-tyrosine_phosphatase-like.)
Pfam PF00041 (fn3)
PF00102 (Y_phosphatase)

Target Cross References - Structure

PDBe 2AHS 2H02 2H03 2H04 2HC1 2HC2 2I3R 2I3U 2I4E 2I4G 2I4H 2I5X
CREDO 2AHS 2H02 2H03 2H04 2HC1 2HC2 2I3R 2I3U 2I4E 2I4G 2I4H 2I5X