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Target Report Card

Target Name and Classification

Target ID CHEMBL2695
Preferred Name Focal adhesion kinase 1
Synonyms FADK 1 | FAK | FAK1 | FRNK | Focal adhesion kinase 1 | Focal adhesion kinase-related nonkinase | PPP1R71 | PTK2 | Protein phosphatase 1 regulatory subunit 71 | Protein-tyrosine kinase 2 | p125FAK | pp125FAK
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase fak family

Target Components

Component Description Relationship Accession
Focal adhesion kinase 1 SINGLE PROTEIN Q05397

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000169398
Ensembl ENSG00000169398
GO Cellular Component GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0005925 (focal adhesion)
GO Molecular Function GO:0004715 (non-membrane spanning protein tyrosine kinase activity)
GO:0004871 (signal transducer activity)
GO:0005524 (ATP binding)
GO:0008432 (JUN kinase binding)
GO:0042169 (SH2 domain binding)
GO Biological Process GO:0006921 (cellular component disassembly involved in apoptosis)
GO:0007172 (signal complex assembly)
GO:0007229 (integrin-mediated signaling pathway)
GO:0007411 (axon guidance)
GO:0007596 (blood coagulation)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0033628 (regulation of cell adhesion mediated by integrin)
GO:0046777 (protein autophosphorylation)
GO:0048013 (ephrin receptor signaling pathway)
GO:0060396 (growth hormone receptor signaling pathway)
Wikipedia PTK2

Target Cross References - Protein

canSAR Q05397
Human Protein Atlas ENSG00000169398
IntAct Q05397
PharmGKB PA33955
Reactome REACT_13552 (Integrin cell surface interactions.)
REACT_18266 (Axon guidance.)
REACT_20676 (Cell junction organization.)
REACT_23853 (Interactions of the immunoglobulin superfamily (IgSF) member proteins.)
REACT_578 (Apoptosis.)
REACT_604 (Hemostasis.)
UniProt Q05397 Q14291 Q9UD85

Target Cross References - Domain

InterPro IPR000299 (FERM_domain.)
IPR000719 (Prot_kinase_cat_dom.)
IPR001245 (Ser-Thr/Tyr-Pkinase.)
IPR005189 (Focal_adhesion_kin_target_dom.)
IPR008266 (Tyr_prot_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR014352 (FERM/acyl-CoA-bd_prot_3-hlx.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR019748 (FERM_central.)
IPR019749 (Band_41_domain.)
IPR020635 (Tyr_Pkinase_cat_dom.)
Pfam PF00373 (FERM_M)
PF03623 (Focal_AT)
PF07714 (Pkinase_Tyr)

Target Cross References - Structure

PDBe 1K04 1K05 1MP8 1OW6 1OW7 1OW8 2ETM 2IJM 2RA7 3B71 3BZ3
CREDO 1K04 1K05 1MP8 1OW6 1OW7 1OW8 2ETM 2IJM 2RA7 3B71 3BZ3