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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2693
Target Type SINGLE PROTEIN
Preferred Name Cystinyl aminopeptidase
Synonyms Cystinyl aminopeptidase | IRAP | Insulin-regulated membrane aminopeptidase | Insulin-responsive aminopeptidase | LNPEP | Leucyl-cystinyl aminopeptidase | Leucyl-cystinyl aminopeptidase, pregnancy serum form | OTASE | OTase | Oxytocinase | P-LAP | Placental leucine aminopeptidase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > metallo protease > metallo protease mae clan > metallo protease m1 family

Target Components

Component Description Relationship Accession
Leucyl-cystinyl aminopeptidase SINGLE PROTEIN Q9UIQ6

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3831223 Aminopeptidase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000113441
Ensembl ENSG00000113441
GO Cellular Component GO:0005576 (extracellular region)
GO:0005622 (intracellular)
GO:0005765 (lysosomal membrane)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030659 (cytoplasmic vesicle membrane)
GO:0031905 (early endosome lumen)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0004177 (aminopeptidase activity)
GO:0005515 (protein binding)
GO:0008233 (peptidase activity)
GO:0008237 (metallopeptidase activity)
GO:0008270 (zinc ion binding)
GO:0016787 (hydrolase activity)
GO:0042277 (peptide binding)
GO:0046872 (metal ion binding)
GO:0070006 (metalloaminopeptidase activity)
GO Biological Process GO:0000209 (protein polyubiquitination)
GO:0002480 (antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)
GO:0006508 (proteolysis)
GO:0007165 (signal transduction)
GO:0007267 (cell-cell signaling)
GO:0007565 (female pregnancy)
GO:0008217 (regulation of blood pressure)
GO:0030163 (protein catabolic process)
GO:0043171 (peptide catabolic process)
GO:0060395 (SMAD protein signal transduction)
GO:0061024 (membrane organization)
Wikipedia Cystinyl_aminopeptidase

Target Cross References - Protein

canSAR Q9UIQ6
Human Protein Atlas ENSG00000113441
IntAct Q9UIQ6
Guide to Pharmacology 1570
Open Targets ENSG00000113441
PharmGKB PA30418
Reactome R-HSA-1236977 (Endosomal/Vacuolar pathway.)
R-HSA-1445148 (Translocation of GLUT4 to the plasma membrane.)
R-HSA-983168 (Antigen processing: Ubiquitination & Proteasome degradation.)
UniProt O00769 Q15145 Q59H76 Q9TNQ2 Q9TNQ3 Q9UIQ6 Q9UIQ7

Target Cross References - Domain

InterPro IPR001930 (Peptidase_M1.)
IPR014782 (Peptidase_M1_N.)
IPR024571 (ERAP1-like_C_dom.)
IPR034016 (M1_APN-typ.)
IPR034017 (Cystinyl_aminopeptidase.)
Pfam PF01433 (Peptidase_M1)
PF11838 (ERAP1_C)

Target Cross References - Structure

PDBe 4P8Q 4PJ6 4Z7I 5C97 5JHQ
CREDO 4P8Q 4PJ6 4Z7I 5C97 5JHQ
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