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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2688
Target Type SINGLE PROTEIN
Preferred Name Hexokinase type I
Synonyms Brain form hexokinase | HK I | HK1 | Hexokinase type I | Hexokinase-1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Hexokinase-1 SINGLE PROTEIN P19367

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000156515
Ensembl ENSG00000156515
GO Cellular Component GO:0005739 (mitochondrion)
GO:0005741 (mitochondrial outer membrane)
GO:0005829 (cytosol)
GO:0005929 (cilium)
GO:0016020 (membrane)
GO:0045121 (membrane raft)
GO:0097228 (sperm principal piece)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003824 (catalytic activity)
GO:0004340 (glucokinase activity)
GO:0004396 (hexokinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0005536 (glucose binding)
GO:0008865 (fructokinase activity)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0016773 (phosphotransferase activity, alcohol group as acceptor)
GO:0019158 (mannokinase activity)
GO Biological Process GO:0001678 (cellular glucose homeostasis)
GO:0005975 (carbohydrate metabolic process)
GO:0006096 (glycolytic process)
GO:0008152 (metabolic process)
GO:0015758 (glucose transport)
GO:0016310 (phosphorylation)
GO:0019318 (hexose metabolic process)
GO:0046835 (carbohydrate phosphorylation)
GO:0051156 (glucose 6-phosphate metabolic process)
GO:0061621 (canonical glycolysis)
GO:0072655 (establishment of protein localization to mitochondrion)
GO:0072656 (maintenance of protein location in mitochondrion)
Wikipedia HK1

Target Cross References - Protein

canSAR P19367
CGD Hemolytic anemia, nonspherocytic, due to hexokinase deficiency
Human Protein Atlas ENSG00000156515
IntAct P19367
Open Targets ENSG00000156515
PharmGKB PA29300
Pharos P19367 (Tbio)
Reactome R-HSA-70153 (Glucose transport.)
R-HSA-70171 (Glycolysis.)
UniProt E9PCK0 O43443 O43444 O75574 P19367 Q5VTC3 Q96HC8 Q9NNZ4 Q9NNZ5

Target Cross References - Domain

InterPro IPR001312 (Hexokinase.)
IPR019807 (Hexokinase_BS.)
IPR022672 (Hexokinase_N.)
IPR022673 (Hexokinase_C.)
Pfam PF00349 (Hexokinase_1)
PF03727 (Hexokinase_2)

Target Cross References - Structure

PDBe 1CZA 1DGK 1HKB 1HKC 1QHA 4F9O 4FOE 4FOI 4FPA 4FPB
CREDO 1CZA 1DGK 1HKB 1HKC 1QHA 4F9O 4FOE 4FOI 4FPA 4FPB
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