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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2688
Target Type SINGLE PROTEIN
Preferred Name Hexokinase type I
Synonyms Brain form hexokinase | HK I | HK1 | Hexokinase type I | Hexokinase-1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Hexokinase-1 SINGLE PROTEIN P19367

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000156515
Ensembl ENSG00000156515
GO Cellular Component GO:0005634 (nucleus)
GO:0005739 (mitochondrion)
GO:0005741 (mitochondrial outer membrane)
GO:0005829 (cytosol)
GO Molecular Function GO:0004340 (glucokinase activity)
GO:0004396 (hexokinase activity)
GO:0005524 (ATP binding)
GO:0005536 (glucose binding)
GO:0008865 (fructokinase activity)
GO:0019158 (mannokinase activity)
GO Biological Process GO:0001678 (cellular glucose homeostasis)
GO:0005975 (carbohydrate metabolic process)
GO:0006006 (glucose metabolic process)
GO:0006096 (glycolysis)
GO:0006096 (glycolytic process)
GO:0008645 (hexose transport)
GO:0015758 (glucose transport)
GO:0044281 (small molecule metabolic process)
GO:0051156 (glucose 6-phosphate metabolic process)
GO:0055085 (transmembrane transport)
GO:0061621 (canonical glycolysis)
GO:0072655 (establishment of protein localization to mitochondrion)
GO:0072656 (maintenance of protein location in mitochondrion)
GO:1903599 (positive regulation of mitophagy)
Wikipedia HK1

Target Cross References - Protein

canSAR P19367
CGD Hemolytic anemia, nonspherocytic, due to hexokinase deficiency
Human Protein Atlas ENSG00000156515
IntAct P19367
PharmGKB PA29300
UniProt O43443 O43444 O75574 P19367 Q5VTC3 Q96HC8 Q9NNZ4 Q9NNZ5

Target Cross References - Domain

InterPro IPR001312 (Hexokinase.)
IPR019807 (Hexokinase_BS.)
IPR019807 (Hexokinase_CS.)
IPR022672 (Hexokinase_N.)
IPR022673 (Hexokinase_C.)
Pfam PF00349 (Hexokinase_1)
PF03727 (Hexokinase_2)

Target Cross References - Structure

PDBe 1CZA 1DGK 1HKB 1HKC 1QHA 4F9O 4FOE 4FOI 4FPA 4FPB
CREDO 1CZA 1DGK 1HKB 1HKC 1QHA 4F9O 4FOE 4FOI 4FPA 4FPB
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