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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2688
Target Type SINGLE PROTEIN
Preferred Name Hexokinase type I
Synonyms Brain form hexokinase | HK I | HK1 | Hexokinase type I | Hexokinase-1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Hexokinase-1 SINGLE PROTEIN P19367

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000156515
Ensembl ENSG00000156515
GO Cellular Component GO:0005634 (nucleus)
GO:0005741 (mitochondrial outer membrane)
GO:0005829 (cytosol)
GO Molecular Function GO:0004340 (glucokinase activity)
GO:0005524 (ATP binding)
GO Biological Process GO:0006096 (glycolysis)
GO:0015758 (glucose transport)
GO:0055085 (transmembrane transport)
Wikipedia HK1

Target Cross References - Protein

canSAR P19367
CGD Hemolytic anemia, nonspherocytic, due to hexokinase deficiency
Human Protein Atlas ENSG00000156515
IntAct P19367
PharmGKB PA29300
Reactome REACT_15518 (Transmembrane transport of small molecules.)
REACT_474 (Metabolism of carbohydrates.)
UniProt O43443 O43444 O75574 P19367 Q5VTC3 Q96HC8 Q9NNZ4 Q9NNZ5

Target Cross References - Domain

InterPro IPR001312 (Hexokinase.)
IPR019807 (Hexokinase_CS.)
IPR022672 (Hexokinase_N.)
IPR022673 (Hexokinase_C.)
Pfam PF00349 (Hexokinase_1)
PF03727 (Hexokinase_2)

Target Cross References - Structure

PDBe 1CZA 1DGK 1HKB 1HKC 1QHA
CREDO 1CZA 1DGK 1HKB 1HKC 1QHA
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