ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL2685
Target Type SINGLE PROTEIN
Preferred Name Collagen alpha 2 chain
Synonyms Alpha-2 type I collagen | COL1A2 | Collagen alpha-2(I) chain
Organism Homo sapiens
Species Group No
Protein Target Classification
  • structural protein

Target Components

Component Description Relationship Accession
Collagen alpha-2(I) chain SINGLE PROTEIN P08123

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2364188 Collagen PROTEIN COMPLEX GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000164692
Ensembl ENSG00000164692
GO Cellular Component GO:0005576 (extracellular region)
GO:0005578 (proteinaceous extracellular matrix)
GO:0005581 (collagen trimer)
GO:0005584 (collagen type I trimer)
GO:0005615 (extracellular space)
GO:0005788 (endoplasmic reticulum lumen)
GO:0031012 (extracellular matrix)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0005201 (extracellular matrix structural constituent)
GO:0005515 (protein binding)
GO:0030674 (protein binding, bridging)
GO:0042802 (identical protein binding)
GO:0046332 (SMAD binding)
GO:0046872 (metal ion binding)
GO:0048407 (platelet-derived growth factor binding)
GO Biological Process GO:0001501 (skeletal system development)
GO:0001568 (blood vessel development)
GO:0007179 (transforming growth factor beta receptor signaling pathway)
GO:0007266 (Rho protein signal transduction)
GO:0007596 (blood coagulation)
GO:0008217 (regulation of blood pressure)
GO:0030168 (platelet activation)
GO:0030198 (extracellular matrix organization)
GO:0030199 (collagen fibril organization)
GO:0030574 (collagen catabolic process)
GO:0042476 (odontogenesis)
GO:0043589 (skin morphogenesis)
GO:0050776 (regulation of immune response)
GO:0050900 (leukocyte migration)
GO:0070208 (protein heterotrimerization)
GO:0071230 (cellular response to amino acid stimulus)
Wikipedia COL1A2

Target Cross References - Protein

CGD Ehlers-Danlos syndrome, cardiac valvular form
Human Protein Atlas ENSG00000164692
IntAct P08123
Open Targets ENSG00000164692
PharmGKB PA35042
Reactome R-HSA-114604 (GPVI-mediated activation cascade.)
R-HSA-1442490 (Collagen degradation.)
R-HSA-1474244 (Extracellular matrix organization.)
R-HSA-1650814 (Collagen biosynthesis and modifying enzymes.)
R-HSA-198933 (Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.)
R-HSA-2022090 (Assembly of collagen fibrils and other multimeric structures.)
R-HSA-202733 (Cell surface interactions at the vascular wall.)
R-HSA-216083 (Integrin cell surface interactions.)
R-HSA-2214320 (Anchoring fibril formation.)
R-HSA-2243919 (Crosslinking of collagen fibrils.)
R-HSA-3000170 (Syndecan interactions.)
R-HSA-3000171 (Non-integrin membrane-ECM interactions.)
R-HSA-3000178 (ECM proteoglycans.)
R-HSA-3000480 (Scavenging by Class A Receptors.)
R-HSA-430116 (GP1b-IX-V activation signalling.)
R-HSA-6785807 (Interleukin-4 and 13 signaling.)
R-HSA-75892 (Platelet Adhesion to exposed collagen.)
R-HSA-76009 (Platelet Aggregation (Plug Formation).)
R-HSA-8874081 (MET activates PTK2 signaling.)
R-HSA-8948216 (Collagen chain trimerization.)
UniProt P02464 P08123 Q13897 Q13997 Q13998 Q14038 Q14057 Q15177 Q15947 Q16480 Q16511 Q7Z5S6 Q9UEB6 Q9UEF9 Q9UM83 Q9UMI1 Q9UML5 Q9UMM6 Q9UPH0

Target Cross References - Domain

InterPro IPR000885 (Fib_collagen_C.)
IPR008160 (Collagen.)
Pfam PF01391 (Collagen)
PF01410 (COLFI)

Target Cross References - Structure

PDBe 5CTD 5CTI 5CVA
CREDO 5CTD 5CTI 5CVA
spacer
spacer