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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2685
Preferred Name Collagen alpha 2 chain
Synonyms Alpha-2 type I collagen | COL1A2 | Collagen alpha-2(I) chain
Organism Homo sapiens
Species Group No
Protein Target Classification
  • structural protein

Target Components

Component Description Relationship Accession
Collagen alpha-2(I) chain SINGLE PROTEIN P08123

Target Relations

ChEMBL ID Pref Name Target Type

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000164692
Ensembl ENSG00000164692
GO Cellular Component GO:0005576 (extracellular region)
GO:0005578 (proteinaceous extracellular matrix)
GO:0005581 (collagen trimer)
GO:0005584 (collagen type I trimer)
GO:0005615 (extracellular space)
GO:0005788 (endoplasmic reticulum lumen)
GO:0031012 (extracellular matrix)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0005201 (extracellular matrix structural constituent)
GO:0005515 (protein binding)
GO:0030674 (protein binding, bridging)
GO:0042802 (identical protein binding)
GO:0046332 (SMAD binding)
GO:0046872 (metal ion binding)
GO:0048407 (platelet-derived growth factor binding)
GO Biological Process GO:0001501 (skeletal system development)
GO:0001568 (blood vessel development)
GO:0007179 (transforming growth factor beta receptor signaling pathway)
GO:0007266 (Rho protein signal transduction)
GO:0007596 (blood coagulation)
GO:0008217 (regulation of blood pressure)
GO:0030168 (platelet activation)
GO:0030198 (extracellular matrix organization)
GO:0030199 (collagen fibril organization)
GO:0030574 (collagen catabolic process)
GO:0042476 (odontogenesis)
GO:0043589 (skin morphogenesis)
GO:0050776 (regulation of immune response)
GO:0050900 (leukocyte migration)
GO:0070208 (protein heterotrimerization)
GO:0071230 (cellular response to amino acid stimulus)
Wikipedia COL1A2

Target Cross References - Protein

CGD Ehlers-Danlos syndrome, cardiac valvular form
Human Protein Atlas ENSG00000164692
IntAct P08123
Open Targets ENSG00000164692
PharmGKB PA35042
Reactome R-HSA-114604 (GPVI-mediated activation cascade.)
R-HSA-1442490 (Collagen degradation.)
R-HSA-1474244 (Extracellular matrix organization.)
R-HSA-1650814 (Collagen biosynthesis and modifying enzymes.)
R-HSA-198933 (Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.)
R-HSA-2022090 (Assembly of collagen fibrils and other multimeric structures.)
R-HSA-202733 (Cell surface interactions at the vascular wall.)
R-HSA-216083 (Integrin cell surface interactions.)
R-HSA-2214320 (Anchoring fibril formation.)
R-HSA-2243919 (Crosslinking of collagen fibrils.)
R-HSA-3000170 (Syndecan interactions.)
R-HSA-3000171 (Non-integrin membrane-ECM interactions.)
R-HSA-3000178 (ECM proteoglycans.)
R-HSA-3000480 (Scavenging by Class A Receptors.)
R-HSA-75892 (Platelet Adhesion to exposed collagen.)
UniProt P02464 P08123 Q13897 Q13997 Q13998 Q14038 Q14057 Q15177 Q15947 Q16480 Q16511 Q7Z5S6 Q9UEB6 Q9UEF9 Q9UM83 Q9UMI1 Q9UML5 Q9UMM6 Q9UPH0

Target Cross References - Domain

InterPro IPR000885 (Fib_collagen_C.)
IPR008160 (Collagen.)
Pfam PF01391 (Collagen)
PF01410 (COLFI)