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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL268
Target Type SINGLE PROTEIN
Preferred Name Cathepsin K
Synonyms CTSK | CTSO | CTSO2 | Cathepsin K | Cathepsin O | Cathepsin O2 | Cathepsin X
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > cysteine protease > cysteine protease ca clan > cysteine protease c1a family

Target Components

Component Description Relationship Accession
Cathepsin K SINGLE PROTEIN P43235

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111380 Cathepsin (L and K) SELECTIVITY GROUP
CHEMBL2111396 Cathepsin (B and K) SELECTIVITY GROUP
CHEMBL2111368 Cathepsin (S and K) SELECTIVITY GROUP
CHEMBL2111441 Cathepsin (H and K) SELECTIVITY GROUP
CHEMBL2111361 Cathepsin (V and K) SELECTIVITY GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000143387
Ensembl ENSG00000143387
GO Cellular Component GO:0005764 (lysosome)
GO Molecular Function GO:0004197 (cysteine-type endopeptidase activity)
GO:0005515 (protein binding)
GO Biological Process GO:0006508 (proteolysis)
Wikipedia Cathepsin_K

Target Cross References - Protein

canSAR P43235
CGD Pycnodysostosis
Human Protein Atlas ENSG00000143387
IntAct P43235
PharmGKB PA27034

Target Cross References - Domain

InterPro IPR000169 (Pept_cys_AS.)
IPR000668 (Peptidase_C1A_C.)
IPR013128 (Peptidase_C1A.)
IPR013201 (Prot_inhib_I29.)
IPR015644 (Peptidase_C1A_cathepsin-K.)
Pfam PF00112 (Peptidase_C1)
PF08246 (Inhibitor_I29)

Target Cross References - Structure

PDBe 1ATK 1AU0 1AU2 1AU3 1AU4 1AYU 1AYV 1AYW 1BGO 1BY8 1MEM 1NL6 1NLJ 1Q6K 1SNK 1TU6 1U9V 1U9W 1U9X 1VSN 1YK7 1YK8 1YT7 2ATO More...
CREDO 1ATK 1AU0 1AU2 1AU3 1AU4 1AYU 1AYV 1AYW 1BGO 1BY8 1MEM 1NL6 1NLJ 1Q6K 1SNK 1TU6 1U9V 1U9W 1U9X 1VSN 1YK7 1YK8 1YT7 2ATO More...
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