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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL268
Target Type SINGLE PROTEIN
Preferred Name Cathepsin K
Synonyms Object
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > cysteine protease > cysteine protease ca clan > cysteine protease c1a family

Target Components

Component Description Relationship Accession
Cathepsin K SINGLE PROTEIN P43235

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111380 Cathepsin (L and K) SELECTIVITY GROUP
CHEMBL2111396 Cathepsin (B and K) SELECTIVITY GROUP
CHEMBL2111368 Cathepsin (S and K) SELECTIVITY GROUP
CHEMBL2111441 Cathepsin (H and K) SELECTIVITY GROUP
CHEMBL2111361 Cathepsin (V and K) SELECTIVITY GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000143387
Ensembl ENSG00000143387
GO Cellular Component GO:0036021 (endolysosome lumen)
GO:0005615 (extracellular space)
GO:0005576 (extracellular region)
GO:0005764 (lysosome)
GO Molecular Function GO:0005518 (collagen binding)
GO:0008234 (cysteine-type peptidase activity)
GO:0043394 (proteoglycan binding)
GO:0004197 (cysteine-type endopeptidase activity)
GO:0001968 (fibronectin binding)
GO Biological Process GO:1903146 (regulation of mitophagy)
GO:0022617 (extracellular matrix disassembly)
GO:0030574 (collagen catabolic process)
GO:0051603 (proteolysis involved in cellular protein catabolic process)
GO:1903955 (positive regulation of protein targeting to mitochondrion)
GO:0001957 (intramembranous ossification)
GO:0030198 (extracellular matrix organization)
GO:0045087 (innate immune response)
GO:0006508 (proteolysis)
GO:0045453 (bone resorption)
GO:0002224 (toll-like receptor signaling pathway)
Wikipedia Cathepsin_K

Target Cross References - Protein

canSAR P43235
CGD Pycnodysostosis
Human Protein Atlas ENSG00000143387
IntAct P43235
Guide to Pharmacology 2350 (cathepsin K)
PharmGKB PA27034
UniProt P43235

Target Cross References - Domain

InterPro IPR000668 (Peptidase_C1A_C.)
IPR013128 (Peptidase_C1A.)
IPR025661 (Pept_asp_AS.)
IPR013201 (Prot_inhib_I29.)
IPR015644 (Peptidase_C1A_cathepsin-K.)
IPR000169 (Pept_cys_AS.)
IPR025660 (Pept_his_AS.)
Pfam PF00112 (Peptidase_C1)
PF08246 (Inhibitor_I29)

Target Cross References - Structure

PDBe 1AU2 1BGO 1NL6 1U9W 3KX1 1ATK 1AYV 1MEM 1U9X 1YK7 2AUX 3C9E 3KWZ 3O0U 4DMX 4X6H 4X6J 1Q6K 1U9V 4X6I 1AYW 1YK8 3KW9 4LEG More...
CREDO 1AU2 1BGO 1NL6 1U9W 3KX1 1ATK 1AYV 1MEM 1U9X 1YK7 2AUX 3C9E 3KWZ 3O0U 4DMX 4X6H 4X6J 1Q6K 1U9V 4X6I 1AYW 1YK8 3KW9 4LEG More...
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