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Target Report Card

Target Name and Classification

Target ID CHEMBL2670
Preferred Name P2X purinoceptor 6
Synonyms ATP receptor | P2RX6 | P2RXL1 | P2X purinoceptor 6 | P2X6 | P2X6 | P2XM | Purinergic receptor P2X-like 1 | Purinergic receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > p2x receptor

Target Components

Component Description Relationship Accession
P2X purinoceptor 6 SINGLE PROTEIN O15547

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000099957
Ensembl ENSG00000099957
GO Cellular Component GO:0005639 (integral component of nuclear inner membrane)
GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0014069 (postsynaptic density)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030054 (cell junction)
GO:0043025 (neuronal cell body)
GO:0043197 (dendritic spine)
GO Molecular Function GO:0001614 (purinergic nucleotide receptor activity)
GO:0004888 (transmembrane signaling receptor activity)
GO:0004931 (extracellular ATP-gated cation channel activity)
GO:0005216 (ion channel activity)
GO:0005524 (ATP binding)
GO:0015267 (channel activity)
GO:0042802 (identical protein binding)
GO Biological Process GO:0006810 (transport)
GO:0006811 (ion transport)
GO:0006936 (muscle contraction)
GO:0007165 (signal transduction)
GO:0007596 (blood coagulation)
GO:0033198 (response to ATP)
GO:0035590 (purinergic nucleotide receptor signaling pathway)
GO:0051260 (protein homooligomerization)
GO:0051291 (protein heterooligomerization)
GO:0098655 (cation transmembrane transport)
Wikipedia P2RX6

Target Cross References - Protein

Human Protein Atlas ENSG00000099957
IntAct O15547
Open Targets ENSG00000099957
PharmGKB PA162398523
Pharos O15547 (Tbio)
Reactome R-HSA-139853 (Elevation of cytosolic Ca2+ levels.)
R-HSA-418346 (Platelet homeostasis.)
UniProt F6V3D7 O15547 Q32MB6 Q58F04 Q6IC33 Q9UL50

Target Cross References - Domain

InterPro IPR001429 (P2X_purnocptor.)
IPR003049 (P2X6_purnocptor.)
IPR027309 (P2X_extracellular_dom.)
Pfam PF00864 (P2X_receptor)