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Target Report Card

Target Name and Classification

Target ID CHEMBL2665
Target Type SINGLE PROTEIN
Preferred Name Insulin-like growth factor binding protein 5
Synonyms IBP-5 | IBP5 | IGF-binding protein 5 | IGFBP-5 | IGFBP5 | Insulin-like growth factor-binding protein 5
Organism Homo sapiens
Species Group No
Protein Target Classification
  • secreted protein

Target Components

Component Description Relationship Accession
Insulin-like growth factor-binding protein 5 SINGLE PROTEIN P24593

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000115461
Ensembl ENSG00000115461
GO Cellular Component GO:0005576 (extracellular region)
GO:0005622 (intracellular)
GO:0016942 (insulin-like growth factor binding protein complex)
GO:0042567 (insulin-like growth factor ternary complex)
GO Molecular Function GO:0001968 (fibronectin binding)
GO:0005515 (protein binding)
GO:0005520 (insulin-like growth factor binding)
GO:0019838 (growth factor binding)
GO:0031994 (insulin-like growth factor I binding)
GO:0031995 (insulin-like growth factor II binding)
GO Biological Process GO:0001558 (regulation of cell growth)
GO:0001649 (osteoblast differentiation)
GO:0006006 (glucose metabolic process)
GO:0007165 (signal transduction)
GO:0007565 (female pregnancy)
GO:0010906 (regulation of glucose metabolic process)
GO:0014912 (negative regulation of smooth muscle cell migration)
GO:0017148 (negative regulation of translation)
GO:0030336 (negative regulation of cell migration)
GO:0031069 (hair follicle morphogenesis)
GO:0035556 (intracellular signal transduction)
GO:0040008 (regulation of growth)
GO:0042593 (glucose homeostasis)
GO:0043568 (positive regulation of insulin-like growth factor receptor signaling pathway)
GO:0043569 (negative regulation of insulin-like growth factor receptor signaling pathway)
GO:0044267 (cellular protein metabolic process)
GO:0044342 (type B pancreatic cell proliferation)
GO:0045668 (negative regulation of osteoblast differentiation)
GO:0045926 (negative regulation of growth)
GO:0048286 (lung alveolus development)
GO:0048630 (skeletal muscle tissue growth)
GO:0048662 (negative regulation of smooth muscle cell proliferation)
GO:0051146 (striated muscle cell differentiation)
GO:0051897 (positive regulation of protein kinase B signaling)
GO:0060056 (mammary gland involution)
GO:0060416 (response to growth hormone)
GO:0071320 (cellular response to cAMP)
GO:0071407 (cellular response to organic cyclic compound)
GO:1901862 (negative regulation of muscle tissue development)
GO:1904205 (negative regulation of skeletal muscle hypertrophy)
Wikipedia IGFBP5

Target Cross References - Protein

canSAR P24593
Human Protein Atlas ENSG00000115461
IntAct P24593
Open Targets ENSG00000115461
PharmGKB PA29707
Reactome R-HSA-381426 (Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).)
UniProt P24593 Q5U0A3

Target Cross References - Domain

InterPro IPR000716 (Thyroglobulin_1.)
IPR000867 (IGFBP-like.)
IPR009030 (Growth_fac_rcpt_.)
IPR009168 (IGFBP1-6.)
IPR012213 (IGFBP-5.)
IPR017891 (Insulin_GF-bd_Cys-rich_CS.)
IPR022321 (IGFBP_1-6_chordata.)
Pfam PF00086 (Thyroglobulin_1)
PF00219 (IGFBP)

Target Cross References - Structure

PDBe 1H59
CREDO 1H59
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