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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL264
Preferred Name Histamine H3 receptor
Synonyms G-protein coupled receptor 97 | GPCR97 | H3R | HH3R | HRH3 | Histamine H3 receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > histamine receptor

Target Components

Component Description Relationship Accession
Histamine H3 receptor SINGLE PROTEIN Q9Y5N1

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111378 Histamine receptor (H3 and H4) SELECTIVITY GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Expression Atlas ENSG00000101180
Ensembl ENSG00000101180
GO Cellular Component GO:0005887 (integral to plasma membrane)
GO Molecular Function GO:0004969 (histamine receptor activity)
GO Biological Process GO:0007187 (G-protein signaling, coupled to cyclic nucleotide second messenger)
GO:0007269 (neurotransmitter secretion)
Wikipedia Histamine_H3_receptor

Target Cross References - Protein

canSAR Q9Y5N1
Human Protein Atlas ENSG00000101180
Guide to Pharmacology 264 (H3)
MICAD NBK23693 (Histamine H3 receptor)
PharmGKB PA29458
Reactome REACT_14797 (Signaling by GPCR.)
UniProt Q4QRI7 Q9GZX2 Q9H4K8 Q9Y5N1

Target Cross References - Domain

InterPro IPR000276 (7TM_GPCR_Rhodpsn.)
IPR003980 (Histamine_H3_recept.)
IPR017452 (GPCR_Rhodpsn_supfam.)
Pfam PF00001 (7tm_1)