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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2634
Target Type SINGLE PROTEIN
Preferred Name Tyrosine-protein kinase CSK
Synonyms C-Src kinase | CSK | Protein-tyrosine kinase CYL | Tyrosine-protein kinase CSK
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase csk family

Target Components

Component Description Relationship Accession
Tyrosine-protein kinase CSK SINGLE PROTEIN P41240

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000103653
Ensembl ENSG00000103653
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005794 (Golgi apparatus)
GO:0005813 (centrosome)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005911 (cell-cell junction)
GO:0031234 (extrinsic component of cytoplasmic side of plasma membrane)
GO:0045121 (membrane raft)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004713 (protein tyrosine kinase activity)
GO:0004715 (non-membrane spanning protein tyrosine kinase activity)
GO:0005102 (receptor binding)
GO:0005524 (ATP binding)
GO:0008022 (protein C-terminus binding)
GO:0034236 (protein kinase A catalytic subunit binding)
GO:0042802 (identical protein binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0001817 (regulation of cytokine production)
GO:0002009 (morphogenesis of an epithelium)
GO:0002250 (adaptive immune response)
GO:0006468 (protein phosphorylation)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0007173 (epidermal growth factor receptor signaling pathway)
GO:0007420 (brain development)
GO:0007596 (blood coagulation)
GO:0008285 (negative regulation of cell proliferation)
GO:0010989 (negative regulation of low-density lipoprotein particle clearance)
GO:0016477 (cell migration)
GO:0030154 (cell differentiation)
GO:0030168 (platelet activation)
GO:0031295 (T cell costimulation)
GO:0032715 (negative regulation of interleukin-6 production)
GO:0033673 (negative regulation of kinase activity)
GO:0034332 (adherens junction organization)
GO:0038083 (peptidyl-tyrosine autophosphorylation)
GO:0042127 (regulation of cell proliferation)
GO:0042997 (negative regulation of Golgi to plasma membrane protein transport)
GO:0043406 (positive regulation of MAP kinase activity)
GO:0045087 (innate immune response)
GO:0045779 (negative regulation of bone resorption)
GO:0048709 (oligodendrocyte differentiation)
GO:0050765 (negative regulation of phagocytosis)
GO:0050852 (T cell receptor signaling pathway)
GO:0060368 (regulation of Fc receptor mediated stimulatory signaling pathway)
GO:0070373 (negative regulation of ERK1 and ERK2 cascade)
GO:0071375 (cellular response to peptide hormone stimulus)
Wikipedia C-src_tyrosine_kinase

Target Cross References - Protein

canSAR P41240
Human Protein Atlas ENSG00000103653
IntAct P41240
PharmGKB PA26946
UniProt P41240 Q2M3N2 Q6FGZ6

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_cat_dom.)
IPR000719 (Prot_kinase_dom.)
IPR000980 (SH2.)
IPR001245 (Ser-Thr/Tyr-Pkinase.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR001452 (SH3_domain.)
IPR008266 (Tyr_kinase_AS.)
IPR008266 (Tyr_prot_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_Pkinase_cat_dom.)
IPR020635 (Tyr_kinase_cat_dom.)
Pfam PF00017 (SH2)
PF00018 (SH3_1)
PF07714 (Pkinase_Tyr)

Target Cross References - Structure

PDBe 1BYG 1CSK 3D7T 3D7U 3EAC 3EAZ
CREDO 1BYG 1CSK 3D7T 3D7U 3EAC 3EAZ
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