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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2633
Target Type SINGLE PROTEIN
Preferred Name Prostatic acid phosphatase
Synonyms 5'-NT | 5'-nucleotidase | ACPP | Ecto-5'-nucleotidase | PAP | PAPf39 | Prostatic acid phosphatase | TMPase | Thiamine monophosphatase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Prostatic acid phosphatase SINGLE PROTEIN P15309

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000014257
Ensembl ENSG00000014257
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005622 (intracellular)
GO:0005634 (nucleus)
GO:0005764 (lysosome)
GO:0005765 (lysosomal membrane)
GO:0005771 (multivesicular body)
GO:0005886 (plasma membrane)
GO:0012506 (vesicle membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030141 (secretory granule)
GO:0030175 (filopodium)
GO:0031985 (Golgi cisterna)
GO:0045177 (apical part of cell)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0003993 (acid phosphatase activity)
GO:0008253 (5'-nucleotidase activity)
GO:0016787 (hydrolase activity)
GO:0016791 (phosphatase activity)
GO:0033265 (choline binding)
GO:0042131 (thiamine phosphate phosphatase activity)
GO:0042802 (identical protein binding)
GO:0052642 (lysophosphatidic acid phosphatase activity)
GO Biological Process GO:0006144 (purine nucleobase metabolic process)
GO:0006772 (thiamine metabolic process)
GO:0009117 (nucleotide metabolic process)
GO:0016311 (dephosphorylation)
GO:0046085 (adenosine metabolic process)
GO:0051930 (regulation of sensory perception of pain)
GO:0060168 (positive regulation of adenosine receptor signaling pathway)
Wikipedia Prostatic_acid_phosphatase

Target Cross References - Protein

canSAR P15309
Human Protein Atlas ENSG00000014257
IntAct P15309
Open Targets ENSG00000014257
PharmGKB PA24449
Reactome R-HSA-6798695 (Neutrophil degranulation.)
UniProt D3DNC6 P15309 Q5FBY0 Q96KY0 Q96QK9 Q96QM0

Target Cross References - Domain

InterPro IPR000560 (His_Pase_clade-2.)
IPR029033 (His_PPase_superfam.)
IPR033379 (Acid_Pase_AS.)
Pfam PF00328 (His_Phos_2)

Target Cross References - Structure

PDBe 1CVI 1ND5 1ND6 2HPA 3PPD
CREDO 1CVI 1ND5 1ND6 2HPA 3PPD
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