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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2632
Target Type SINGLE PROTEIN
Preferred Name HLA class I histocompatibility antigen A-3
Synonyms HLA class I histocompatibility antigen, A-3 alpha chain | HLA-A | HLAA | MHC class I antigen A*3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • surface antigen

Target Components

Component Description Relationship Accession
HLA class I histocompatibility antigen, A-3 alpha chain SINGLE PROTEIN P04439

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000206503
Ensembl ENSG00000206503
GO Cellular Component GO:0000139 (Golgi membrane)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005794 (Golgi apparatus)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0009986 (cell surface)
GO:0012507 (ER to Golgi transport vesicle membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030670 (phagocytic vesicle membrane)
GO:0031901 (early endosome membrane)
GO:0042612 (MHC class I protein complex)
GO:0055038 (recycling endosome membrane)
GO:0071556 (integral component of lumenal side of endoplasmic reticulum membrane)
GO Molecular Function GO:0030881 (beta-2-microglobulin binding)
GO:0042605 (peptide antigen binding)
GO:0046977 (TAP binding)
GO Biological Process GO:0002376 (immune system process)
GO:0002474 (antigen processing and presentation of peptide antigen via MHC class I)
GO:0002479 (antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)
GO:0002480 (antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)
GO:0006955 (immune response)
GO:0016032 (viral process)
GO:0016567 (protein ubiquitination)
GO:0019882 (antigen processing and presentation)
GO:0050776 (regulation of immune response)
GO:0060333 (interferon-gamma-mediated signaling pathway)
GO:0060337 (type I interferon signaling pathway)
Wikipedia HLA-A

Target Cross References - Protein

canSAR P04439
CGD Drug-induced toxicity, susceptibility to
Human Protein Atlas ENSG00000206503
IntAct P04439
Open Targets ENSG00000206503
PharmGKB PA35055
Reactome R-HSA-1236974 (ER-Phagosome pathway.)
R-HSA-1236977 (Endosomal/Vacuolar pathway.)
R-HSA-198933 (Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.)
R-HSA-877300 (Interferon gamma signaling.)
R-HSA-8866654 (E3 ubiquitin ligases ubiquitinate target proteins.)
R-HSA-909733 (Interferon alpha/beta signaling.)
R-HSA-983170 (Antigen Presentation: Folding, assembly and peptide loading of class I MHC.)
UniProt O19546 O19756 P04439 Q65A82 Q9GJE6 Q9GJE7 Q9GJE8 Q9MYE6 Q9MYG4 Q9TPR8

Target Cross References - Domain

InterPro IPR001039 (MHC_I_a_a1/a2.)
IPR003006 (Ig/MHC_CS.)
IPR003597 (Ig_C1-set.)
IPR007110 (Ig-like_dom.)
IPR010579 (MHC_I_a_C.)
IPR011161 (MHC_I-like_Ag-recog.)
IPR011162 (MHC_I/II-like_Ag-recog.)
IPR013783 (Ig-like_fold.)
IPR036179 (Ig-like_dom_sf.)
IPR037055 (MHC_I-like_Ag-recog_sf.)
Pfam PF00129 (MHC_I)
PF06623 (MHC_I_C)
PF07654 (C1-set)

Target Cross References - Structure

PDBe 2XPG 3RL1 3RL2
CREDO 2XPG 3RL1 3RL2
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