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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL262
Target Type SINGLE PROTEIN
Preferred Name Glycogen synthase kinase-3 beta
Synonyms GSK-3 beta | GSK3B | Glycogen synthase kinase-3 beta | Serine/threonine-protein kinase GSK3B
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > cmgc protein kinase group > cmgc protein kinase gsk family

Target Components

Component Description Relationship Accession
Glycogen synthase kinase-3 beta SINGLE PROTEIN P49841

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095188 Glycogen synthase kinase-3 PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000082701
Ensembl ENSG00000082701
GO Cellular Component GO:0005634 (nucleus)
GO:0005813 (centrosome)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0030877 (beta-catenin destruction complex)
GO:0034747 (Axin-APC-beta-catenin-GSK3B complex)
GO Molecular Function GO:0001085 (RNA polymerase II transcription factor binding)
GO:0002039 (p53 binding)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005524 (ATP binding)
GO:0008013 (beta-catenin binding)
GO:0031625 (ubiquitin protein ligase binding)
GO:0034236 (protein kinase A catalytic subunit binding)
GO:0050321 (tau-protein kinase activity)
GO:0051059 (NF-kappaB binding)
GO Biological Process GO:0001837 (epithelial to mesenchymal transition)
GO:0001954 (positive regulation of cell-matrix adhesion)
GO:0005977 (glycogen metabolic process)
GO:0006983 (ER overload response)
GO:0007411 (axon guidance)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0021766 (hippocampus development)
GO:0031333 (negative regulation of protein complex assembly)
GO:0031334 (positive regulation of protein complex assembly)
GO:0032091 (negative regulation of protein binding)
GO:0032855 (positive regulation of Rac GTPase activity)
GO:0032886 (regulation of microtubule-based process)
GO:0043066 (negative regulation of apoptosis)
GO:0046827 (positive regulation of protein export from nucleus)
GO:0048011 (nerve growth factor receptor signaling pathway)
GO:0048015 (phosphatidylinositol-mediated signaling)
GO:0071109 (superior temporal gyrus development)
Wikipedia GSK3B

Target Cross References - Protein

canSAR P49841
Human Protein Atlas ENSG00000082701
IntAct P49841
PharmGKB PA29009
Reactome REACT_11045 (Signaling by Wnt.)
REACT_11061 (Signalling by NGF.)
REACT_18266 (Axon guidance.)
UniProt D3DN89 P49841 Q9BWH3 Q9UL47

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_cat_dom.)
IPR002290 (Ser/Thr_prot_kinase_dom.)
IPR008271 (Ser/Thr_prot_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR017442 (Se/Thr_prot_kinase-like_dom.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 1GNG 1H8F 1I09 1J1B 1J1C 1O9U 1PYX 1Q3D 1Q3W 1Q41 1Q4L 1Q5K 1R0E 1UV5 2JDO 2JDR 2JLD 2O5K 2OW3 2UW9 2X39 2XH5 3CQU 3CQW More...
CREDO 1GNG 1H8F 1I09 1J1B 1J1C 1O9U 1PYX 1Q3D 1Q3W 1Q41 1Q4L 1Q5K 1R0E 1UV5 2JDO 2JDR 2JLD 2O5K 2OW3 2UW9 2X39 2XH5 3CQU 3CQW More...
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