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Target Report Card

Target Name and Classification

Target ID CHEMBL2616
Target Type SINGLE PROTEIN
Preferred Name Acetyl-CoA acetyltransferase, mitochondrial
Synonyms ACAT | ACAT1 | Acetoacetyl-CoA thiolase | Acetyl-CoA acetyltransferase, mitochondrial | MAT | T2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Acetyl-CoA acetyltransferase, mitochondrial SINGLE PROTEIN P24752

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000075239
Ensembl ENSG00000075239
GO Cellular Component GO:0005739 (mitochondrion)
GO:0005743 (mitochondrial inner membrane)
GO:0005759 (mitochondrial matrix)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0003824 (catalytic activity)
GO:0003985 (acetyl-CoA C-acetyltransferase activity)
GO:0016740 (transferase activity)
GO:0016746 (transferase activity, transferring acyl groups)
GO:0016747 (transferase activity, transferring acyl groups other than amino-acyl groups)
GO:0019899 (enzyme binding)
GO:0042803 (protein homodimerization activity)
GO:0046872 (metal ion binding)
GO:0050662 (coenzyme binding)
GO Biological Process GO:0001889 (liver development)
GO:0007420 (brain development)
GO:0008152 (metabolic process)
GO:0009083 (branched-chain amino acid catabolic process)
GO:0009725 (response to hormone)
GO:0014070 (response to organic cyclic compound)
GO:0042594 (response to starvation)
GO:0046951 (ketone body biosynthetic process)
GO:0046952 (ketone body catabolic process)
GO:0051260 (protein homooligomerization)
GO:0060612 (adipose tissue development)
GO:0072229 (metanephric proximal convoluted tubule development)
Wikipedia ACAT1

Target Cross References - Protein

canSAR P24752
CGD 3-oxothiolase deficiency
Human Protein Atlas ENSG00000075239
IntAct P24752
Open Targets ENSG00000075239
PharmGKB PA24431
Reactome R-HSA-70895 (Branched-chain amino acid catabolism.)
R-HSA-77108 (Utilization of Ketone Bodies.)
R-HSA-77111 (Synthesis of Ketone Bodies.)
UniProt B2R6H1 G3XAB4 P24752 Q96FG8

Target Cross References - Domain

InterPro IPR002155 (Thiolase.)
IPR016039 (Thiolase-like.)
IPR020610 (Thiolase_AS.)
IPR020613 (Thiolase_CS.)
IPR020615 (Thiolase_acyl_enz_int_AS.)
IPR020616 (Thiolase_N.)
IPR020617 (Thiolase_C.)
Pfam PF00108 (Thiolase_N)
PF02803 (Thiolase_C)

Target Cross References - Structure

PDBe 2F2S 2IB7 2IB8 2IB9 2IBU 2IBW 2IBY
CREDO 2F2S 2IB7 2IB8 2IB9 2IBU 2IBW 2IBY
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