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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2614
Target Type SINGLE PROTEIN
Preferred Name Glutamate decarboxylase 67 kDa isoform
Synonyms 67 kDa glutamic acid decarboxylase | GAD | GAD-67 | GAD1 | GAD67 | Glutamate decarboxylase 1 | Glutamate decarboxylase 67 kDa isoform
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Glutamate decarboxylase 1 SINGLE PROTEIN Q99259

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000128683
Ensembl ENSG00000128683
GO Cellular Component GO:0005622 (intracellular)
GO:0005886 (plasma membrane)
GO:0012506 (vesicle membrane)
GO:0048786 (presynaptic active zone)
GO:0061202 (clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane)
GO Molecular Function GO:0003824 (catalytic activity)
GO:0004351 (glutamate decarboxylase activity)
GO:0005515 (protein binding)
GO:0016595 (glutamate binding)
GO:0016829 (lyase activity)
GO:0016831 (carboxy-lyase activity)
GO:0030170 (pyridoxal phosphate binding)
GO:0046982 (protein heterodimerization activity)
GO:0047485 (protein N-terminus binding)
GO Biological Process GO:0006538 (glutamate catabolic process)
GO:0006540 (glutamate decarboxylation to succinate)
GO:0007268 (chemical synaptic transmission)
GO:0007269 (neurotransmitter secretion)
GO:0009449 (gamma-aminobutyric acid biosynthetic process)
GO:0018352 (protein-pyridoxal-5-phosphate linkage)
GO:0019752 (carboxylic acid metabolic process)
GO:0042136 (neurotransmitter biosynthetic process)
GO:0042493 (response to drug)
Wikipedia GAD1

Target Cross References - Protein

canSAR Q99259
CGD Cerebral palsy, spastic quadriplegic, 1
Human Protein Atlas ENSG00000128683
IntAct Q99259
Open Targets ENSG00000128683
PharmGKB PA28507
Reactome R-HSA-888568 (GABA synthesis.)
R-HSA-888590 (GABA synthesis, release, reuptake and degradation.)
UniProt Q49AK1 Q53TQ7 Q99259 Q9BU91 Q9UHH4

Target Cross References - Domain

InterPro IPR002129 (PyrdxlP-dep_de-COase.)
IPR015421 (PyrdxlP-dep_Trfase_major_sub1.)
IPR015422 (PyrdxlP-dep_Trfase_major_sub2.)
IPR015424 (PyrdxlP-dep_Trfase.)
IPR021115 (Pyridoxal-P_BS.)
Pfam PF00282 (Pyridoxal_deC)

Target Cross References - Structure

PDBe 2OKJ 3VP6
CREDO 2OKJ 3VP6
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