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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2612
Target Type SINGLE PROTEIN
Preferred Name Valyl-tRNA synthetase 2
Synonyms G7A | Protein G7a | VARS | VARS2 | ValRS | Valine--tRNA ligase | Valyl-tRNA synthetase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Valine--tRNA ligase SINGLE PROTEIN P26640

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000096171 ENSG00000204394 ENSG00000224264 ENSG00000226589 ENSG00000231116
Ensembl ENSG00000096171 ENSG00000204394 ENSG00000224264 ENSG00000226589 ENSG00000231116
GO Cellular Component GO:0005739 (mitochondrion)
GO:0005829 (cytosol)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0002161 (aminoacyl-tRNA editing activity)
GO:0004812 (aminoacyl-tRNA ligase activity)
GO:0004832 (valine-tRNA ligase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016874 (ligase activity)
GO Biological Process GO:0006412 (translation)
GO:0006418 (tRNA aminoacylation for protein translation)
GO:0006438 (valyl-tRNA aminoacylation)
GO:0006450 (regulation of translational fidelity)
Wikipedia VARS

Target Cross References - Protein

canSAR P26640
Human Protein Atlas ENSG00000096171 ENSG00000204394 ENSG00000224264 ENSG00000226589 ENSG00000231116
IntAct P26640
Open Targets ENSG00000096171 ENSG00000204394 ENSG00000224264 ENSG00000226589 ENSG00000231116
PharmGKB PA37275
Reactome R-HSA-379716 (Cytosolic tRNA aminoacylation.)
UniProt B0V1N1 B4DZ61 P26640 Q5JQ90 Q96E77 Q9UQM2

Target Cross References - Domain

InterPro IPR001412 (aa-tRNA-synth_I_CS.)
IPR002300 (aa-tRNA-synth_Ia.)
IPR002303 (Valyl-tRNA_ligase.)
IPR004046 (GST_C.)
IPR009008 (Val/Leu/Ile-tRNA-synth_edit.)
IPR009080 (tRNAsynth_Ia_anticodon-bd.)
IPR010987 (Glutathione-S-Trfase_C-like.)
IPR013155 (M/V/L/I-tRNA-synth_anticd-bd.)
IPR014729 (Rossmann-like_a/b/a_fold.)
IPR033705 (Anticodon_Ia_Val.)
Pfam PF00043 (GST_C)
PF00133 (tRNA-synt_1)
PF08264 (Anticodon_1)
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