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Target Report Card

Target Name and Classification

Target ID CHEMBL2611
Preferred Name Furin
Synonyms Dibasic-processing enzyme | FUR | FURIN | Furin | PACE | PACE | PCSK3 | Paired basic amino acid residue-cleaving enzyme
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > serine protease > serine protease sb clan > serine protease s8b subfamily

Target Components

Component Description Relationship Accession

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Expression Atlas ENSG00000140564
Ensembl ENSG00000140564
GO Cellular Component GO:0000139 (Golgi membrane)
GO:0005796 (Golgi lumen)
GO:0005802 (trans-Golgi network)
GO:0005886 (plasma membrane)
GO:0009986 (cell surface)
GO:0016021 (integral to membrane)
GO:0030140 (trans-Golgi network transport vesicle)
GO:0045121 (membrane raft)
GO Molecular Function GO:0002020 (protease binding)
GO:0004252 (serine-type endopeptidase activity)
GO:0004867 (serine-type endopeptidase inhibitor activity)
GO:0042277 (peptide binding)
GO:0046872 (metal ion binding)
GO:0048406 (nerve growth factor binding)
GO Biological Process GO:0006465 (signal peptide processing)
GO:0007179 (transforming growth factor beta receptor signaling pathway)
GO:0007219 (Notch signaling pathway)
GO:0008283 (cell proliferation)
GO:0017187 (peptidyl-glutamic acid carboxylation)
GO:0019067 (viral assembly, maturation, egress, and release)
GO:0032455 (nerve growth factor processing)
GO:0032804 (negative regulation of low-density lipoprotein particle receptor catabolic process)
GO:0032902 (nerve growth factor production)
GO:0032911 (negative regulation of transforming growth factor-beta1 production)
GO:0032940 (secretion by cell)
GO:0043043 (peptide biosynthetic process)
GO:0043687 (post-translational protein modification)
GO:0048011 (nerve growth factor receptor signaling pathway)
Wikipedia Furin

Target Cross References - Protein

canSAR P09958
Human Protein Atlas ENSG00000140564
IntAct P09958
Guide to Pharmacology 2366 (furin (paired basic amino acid cleaving enzyme))
PharmGKB PA32894
Reactome REACT_11061 (Signalling by NGF.)
REACT_16888 (Signaling by PDGF.)
REACT_17015 (Metabolism of proteins.)
REACT_299 (Signaling by Notch.)
REACT_6844 (Signaling by TGF beta.)
UniProt P09958 Q14336 Q6LBS3 Q9UCZ5

Target Cross References - Domain

InterPro IPR000209 (Peptidase_S8/S53.)
IPR002884 (PrprotnconvertsP.)
IPR006212 (Furin_repeat.)
IPR008979 (Galactose-bd-like.)
IPR009020 (Prot_inh_propept.)
IPR009030 (Growth_fac_rcpt.)
IPR015500 (Peptidase_S8_subtilisin-rel.)
IPR022398 (Peptidase_S8_His-AS.)
IPR023827 (Peptidase_S8_Asp-AS.)
IPR023828 (Peptidase_S8_Ser-AS.)
Pfam PF00082 (Peptidase_S8)
PF01483 (P_proprotein)