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Target Report Card

Target Name and Classification

Target ID CHEMBL2611
Target Type SINGLE PROTEIN
Preferred Name Furin
Synonyms Dibasic-processing enzyme | FUR | FURIN | Furin | PACE | PACE | PCSK3 | Paired basic amino acid residue-cleaving enzyme
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > serine protease > serine protease sb clan > serine protease s8b subfamily

Target Components

Component Description Relationship Accession
Furin SINGLE PROTEIN P09958

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000140564
Ensembl ENSG00000140564
GO Cellular Component GO:0000139 (Golgi membrane)
GO:0005615 (extracellular space)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005794 (Golgi apparatus)
GO:0005796 (Golgi lumen)
GO:0005802 (trans-Golgi network)
GO:0005886 (plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030140 (trans-Golgi network transport vesicle)
GO:0031985 (Golgi cisterna)
GO:0045121 (membrane raft)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0002020 (protease binding)
GO:0004175 (endopeptidase activity)
GO:0004252 (serine-type endopeptidase activity)
GO:0004867 (serine-type endopeptidase inhibitor activity)
GO:0005515 (protein binding)
GO:0008233 (peptidase activity)
GO:0008236 (serine-type peptidase activity)
GO:0016787 (hydrolase activity)
GO:0042277 (peptide binding)
GO:0046872 (metal ion binding)
GO:0048406 (nerve growth factor binding)
GO Biological Process GO:0006465 (signal peptide processing)
GO:0006508 (proteolysis)
GO:0007179 (transforming growth factor beta receptor signaling pathway)
GO:0007568 (aging)
GO:0008283 (cell proliferation)
GO:0009966 (regulation of signal transduction)
GO:0010951 (negative regulation of endopeptidase activity)
GO:0016485 (protein processing)
GO:0016486 (peptide hormone processing)
GO:0019058 (viral life cycle)
GO:0019082 (viral protein processing)
GO:0022617 (extracellular matrix disassembly)
GO:0030198 (extracellular matrix organization)
GO:0030335 (positive regulation of cell migration)
GO:0030511 (positive regulation of transforming growth factor beta receptor signaling pathway)
GO:0030574 (collagen catabolic process)
GO:0032455 (nerve growth factor processing)
GO:0032804 (negative regulation of low-density lipoprotein particle receptor catabolic process)
GO:0032902 (nerve growth factor production)
GO:0032904 (negative regulation of nerve growth factor production)
GO:0032911 (negative regulation of transforming growth factor beta1 production)
GO:0032940 (secretion by cell)
GO:0042176 (regulation of protein catabolic process)
GO:0043043 (peptide biosynthetic process)
GO:0044267 (cellular protein metabolic process)
GO:0045714 (regulation of low-density lipoprotein particle receptor biosynthetic process)
GO:0051044 (positive regulation of membrane protein ectodomain proteolysis)
GO:0052548 (regulation of endopeptidase activity)
Wikipedia Furin

Target Cross References - Protein

canSAR P09958
Human Protein Atlas ENSG00000140564
IntAct P09958
Guide to Pharmacology 2366
Open Targets ENSG00000140564
PharmGKB PA32894
Reactome R-HSA-1181150 (Signaling by NODAL.)
R-HSA-1442490 (Collagen degradation.)
R-HSA-1566948 (Elastic fibre formation.)
R-HSA-1592389 (Activation of Matrix Metalloproteinases.)
R-HSA-159782 (Removal of aminoterminal propeptides from gamma-carboxylated proteins.)
R-HSA-167060 (NGF processing.)
R-HSA-171286 (Synthesis and processing of ENV and VPU.)
R-HSA-174800 (Chylomicron-mediated lipid transport.)
R-HSA-186797 (Signaling by PDGF.)
R-HSA-1912420 (Pre-NOTCH Processing in Golgi.)
R-HSA-2173789 (TGF-beta receptor signaling activates SMADs.)
R-HSA-5210891 (Uptake and function of anthrax toxins.)
R-HSA-6809371 (Formation of the cornified envelope.)
R-HSA-977225 (Amyloid fiber formation.)
UniProt P09958 Q14336 Q6LBS3 Q9UCZ5

Target Cross References - Domain

InterPro IPR000209 (Peptidase_S8/S53_dom.)
IPR002884 (PrprotnconvertsP.)
IPR006212 (Furin_repeat.)
IPR008979 (Galactose-bd-like.)
IPR009020 (Propept_inh.)
IPR009030 (Growth_fac_rcpt_.)
IPR015500 (Peptidase_S8_subtilisin-rel.)
IPR022398 (Peptidase_S8_His-AS.)
IPR023827 (Peptidase_S8_Asp-AS.)
IPR023828 (Peptidase_S8_Ser-AS.)
IPR032815 (S8_pro-domain.)
IPR034182 (Kexin/furin.)
Pfam PF00082 (Peptidase_S8)
PF01483 (P_proprotein)
PF16470 (S8_pro-domain)

Target Cross References - Structure

PDBe 4OMC 4OMD 4RYD 4Z2A 5JMO 5JXG 5JXH 5JXI 5JXJ
CREDO 4OMC 4OMD 4RYD 4Z2A 5JMO 5JXG 5JXH 5JXI 5JXJ
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