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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL261
Target Type SINGLE PROTEIN
Preferred Name Carbonic anhydrase I
Synonyms CA-I | CA1 | CAB | Carbonate dehydratase I | Carbonic anhydrase 1 | Carbonic anhydrase B | Carbonic anhydrase I
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > lyase

Target Components

Component Description Relationship Accession
Carbonic anhydrase 1 SINGLE PROTEIN P00915

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095180 Carbonic anhydrase PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL17 DICHLORPHENAMIDE Carbonic anhydrase I inhibitor 4 PubMed
CHEMBL19 METHAZOLAMIDE Carbonic anhydrase I inhibitor 4 DailyMed PubMed
CHEMBL20 ACETAZOLAMIDE Carbonic anhydrase I inhibitor 4 PubMed PubMed
CHEMBL1200814 ACETAZOLAMIDE SODIUM Carbonic anhydrase I inhibitor 4 PubMed PubMed
CHEMBL1201117 METHOCARBAMOL Carbonic anhydrase I inhibitor 4 PubMed
CHEMBL166863 POLMACOXIB Carbonic anhydrase I inhibitor 3 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000133742
Ensembl ENSG00000133742
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004064 (arylesterase activity)
GO:0004089 (carbonate dehydratase activity)
GO:0005515 (protein binding)
GO:0008270 (zinc ion binding)
GO:0016829 (lyase activity)
GO:0016836 (hydro-lyase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006730 (one-carbon metabolic process)
GO:0015701 (bicarbonate transport)
Wikipedia CA1_(gene)

Target Cross References - Protein

canSAR P00915
Human Protein Atlas ENSG00000133742
IntAct P00915
Guide to Pharmacology 2597
Open Targets ENSG00000133742
PharmGKB PA25984
Reactome R-HSA-1237044 (Erythrocytes take up carbon dioxide and release oxygen.)
R-HSA-1247673 (Erythrocytes take up oxygen and release carbon dioxide.)
R-HSA-1475029 (Reversible hydration of carbon dioxide.)
UniProt P00915

Target Cross References - Domain

InterPro IPR001148 (Carbonic_anhydrase_a.)
IPR018338 (Carbonic_anhydrase_a-class_CS.)
IPR018442 (Carbonic_anhydrase_CA1.)
IPR023561 (Carbonic_anhydrase_a-class.)
Pfam PF00194 (Carb_anhydrase)

Target Cross References - Structure

PDBe 1AZM 1BZM 1CRM 1CZM 1HCB 1HUG 1HUH 1J9W 1JV0 2CAB 2FOY 2FW4 2IT4 2NMX 2NN1 2NN7 3LXE 3W6H 3W6I 4WR7 4WUP 4WUQ 5E2M
CREDO 1AZM 1BZM 1CRM 1CZM 1HCB 1HUG 1HUH 1J9W 1JV0 2CAB 2FOY 2FW4 2IT4 2NMX 2NN1 2NN7 3LXE 3W6H 3W6I 4WR7 4WUP 4WUQ 5E2M
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