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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2608
Preferred Name Lysosomal alpha-glucosidase
Synonyms 70 kDa lysosomal alpha-glucosidase | 76 kDa lysosomal alpha-glucosidase | Acid maltase | Aglucosidase alfa | GAA | Lysosomal alpha-glucosidase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > hydrolase

Target Components

Component Description Relationship Accession
Lysosomal alpha-glucosidase SINGLE PROTEIN P10253

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1561 MIGLITOL Lysosomal alpha-glucosidase inhibitor 4 DailyMed PubMed
CHEMBL460785 DUVOGLUSTAT HYDROCHLORIDE Lysosomal alpha-glucosidase stabiliser 2 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000171298
Ensembl ENSG00000171298
GO Cellular Component GO:0005764 (lysosome)
GO:0005765 (lysosomal membrane)
GO:0016020 (membrane)
GO:0043202 (lysosomal lumen)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0003824 (catalytic activity)
GO:0004553 (hydrolase activity, hydrolyzing O-glycosyl compounds)
GO:0004558 (alpha-1,4-glucosidase activity)
GO:0004574 (oligo-1,6-glucosidase activity)
GO:0016787 (hydrolase activity)
GO:0016798 (hydrolase activity, acting on glycosyl bonds)
GO:0030246 (carbohydrate binding)
GO:0032450 (maltose alpha-glucosidase activity)
GO Biological Process GO:0000023 (maltose metabolic process)
GO:0002026 (regulation of the force of heart contraction)
GO:0002086 (diaphragm contraction)
GO:0003007 (heart morphogenesis)
GO:0005975 (carbohydrate metabolic process)
GO:0005977 (glycogen metabolic process)
GO:0005980 (glycogen catabolic process)
GO:0005985 (sucrose metabolic process)
GO:0006006 (glucose metabolic process)
GO:0006941 (striated muscle contraction)
GO:0007040 (lysosome organization)
GO:0007626 (locomotory behavior)
GO:0008152 (metabolic process)
GO:0009888 (tissue development)
GO:0043181 (vacuolar sequestering)
GO:0046716 (muscle cell cellular homeostasis)
GO:0050884 (neuromuscular process controlling posture)
GO:0050885 (neuromuscular process controlling balance)
GO:0060048 (cardiac muscle contraction)
Wikipedia Acid_alpha-glucosidase

Target Cross References - Protein

CGD Glycogen storage disease II
Human Protein Atlas ENSG00000171298
IntAct P10253
Guide to Pharmacology 2611
Open Targets ENSG00000171298
PharmGKB PA28476
Reactome R-HSA-5357572 (Lysosomal glycogen catabolism.)
R-HSA-6798695 (Neutrophil degranulation.)
UniProt P10253 Q09GN4 Q14351 Q16302 Q8IWE7

Target Cross References - Domain

InterPro IPR000322 (Glyco_hydro_31.)
IPR000519 (P_trefoil_dom.)
IPR011013 (Gal_mutarotase_SF_dom.)
IPR017853 (Glycoside_hydrolase_SF.)
IPR017957 (P_trefoil_CS.)
IPR025887 (Glyco_hydro_31_N_dom.)
IPR030458 (Glyco_hydro_31_AS.)
IPR030459 (Glyco_hydro_31_CS.)
IPR031727 (Gal_mutarotase_N.)
Pfam PF00088 (Trefoil)
PF01055 (Glyco_hydro_31)
PF13802 (Gal_mutarotas_2)
PF16863 (NtCtMGAM_N)