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Target Report Card

Target Name and Classification

Target ID CHEMBL260
Target Type SINGLE PROTEIN
Preferred Name MAP kinase p38 alpha
Synonyms CSAID-binding protein | CSBP | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MXI2 | Mitogen-activated protein kinase 14 | Mitogen-activated protein kinase p38 alpha | SAPK2A | SAPK2a | Stress-activated protein kinase 2a
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > cmgc protein kinase group > cmgc protein kinase mapk family > cmgc protein kinase p38 subfamily

Target Components

Component Description Relationship Accession
Mitogen-activated protein kinase 14 SINGLE PROTEIN Q16539

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2094115 MAP kinase p38 PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1088752 LOSMAPIMOD MAP kinase p38 alpha inhibitor 3 PubMed PubMed
CHEMBL9960 AZD-7624 MAP kinase p38 alpha inhibitor 2 DOI Other
CHEMBL103667 DORAMAPIMOD MAP kinase p38 alpha inhibitor 2 PubMed PubMed
CHEMBL119385 VX-745 MAP kinase p38 alpha inhibitor 2 PubMed
CHEMBL363648 TAK-715 MAP kinase p38 alpha inhibitor 2 PubMed
CHEMBL514201 TALMAPIMOD MAP kinase p38 alpha inhibitor 2 PubMed PubMed PubMed
CHEMBL1090089 PAMAPIMOD MAP kinase p38 alpha inhibitor 2 PubMed
CHEMBL1090090 VX-702 MAP kinase p38 alpha inhibitor 2 PubMed
CHEMBL1088750 ARRY-797 MAP kinase p38 alpha inhibitor 2 Other PubMed
CHEMBL1088751 PH-797804 MAP kinase p38 alpha inhibitor 2 PubMed PubMed
CHEMBL1230065 BMS-582949 MAP kinase p38 alpha inhibitor 2 PubMed PubMed
CHEMBL1938400 PF-03715455 MAP kinase p38 alpha inhibitor 2 Other PubMed
CHEMBL2103838 DILMAPIMOD MAP kinase p38 alpha inhibitor 2 Other PubMed PubMed
CHEMBL2107779 SEMAPIMOD MAP kinase p38 alpha inhibitor 2 PubMed
CHEMBL2364626 RALIMETINIB MAP kinase p38 alpha inhibitor 2 PubMed
CHEMBL3545216 FX-005 MAP kinase p38 alpha inhibitor 2 Other
CHEMBL3545226 Acumapimod MAP kinase p38 alpha inhibitor 2 PubMed
CHEMBL3545282 KC-706 MAP kinase p38 alpha inhibitor 2 Other PubMed
CHEMBL3545398 PG-760564 MAP kinase p38 alpha inhibitor 2 Other
CHEMBL190333 RWJ-67657 MAP kinase p38 alpha inhibitor 1 PubMed
CHEMBL203567 Ro-3201195 MAP kinase p38 alpha inhibitor 1 PubMed PubMed
CHEMBL585902 AMG-548 MAP kinase p38 alpha inhibitor 1 PubMed
CHEMBL1090173 SD-0006 MAP kinase p38 alpha inhibitor 1 PubMed PubMed
CHEMBL1614702 SCIO-323 MAP kinase p38 alpha inhibitor 1 PubMed
CHEMBL1766582 R-1487 MAP kinase p38 alpha inhibitor 1 PubMed
CHEMBL2031465 AZD-6703 MAP kinase p38 alpha inhibitor 1 PubMed
CHEMBL3544930 SC-80036 MAP kinase p38 alpha inhibitor 1 PubMed
CHEMBL3544968 GSK-610677 MAP kinase p38 alpha inhibitor 1
CHEMBL3544998 LY-3007113 MAP kinase p38 alpha inhibitor 1 Other
CHEMBL3545074 LEO-15520 MAP kinase p38 alpha inhibitor 1 Other
CHEMBL3545117 AVE-9940 MAP kinase p38 alpha inhibitor 1 Other
CHEMBL3545139 PS-516895 MAP kinase p38 alpha inhibitor 1 Other Other
CHEMBL3545201 TA-5493 MAP kinase p38 alpha inhibitor 1 Other
CHEMBL3545297 Pexmetinib MAP kinase p38 alpha inhibitor 1 Other Other
CHEMBL3545384 SB-85635 MAP kinase p38 alpha inhibitor 1 Other
More...

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000112062
Ensembl ENSG00000112062
GO Cellular Component GO:0000922 (spindle pole)
GO:0005623 (cell)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005829 (cytosol)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004707 (MAP kinase activity)
GO:0004708 (MAP kinase kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008022 (protein C-terminus binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0019899 (enzyme binding)
GO:0019903 (protein phosphatase binding)
GO:0051525 (NFAT protein binding)
GO Biological Process GO:0000077 (DNA damage checkpoint)
GO:0000187 (activation of MAPK activity)
GO:0000902 (cell morphogenesis)
GO:0001502 (cartilage condensation)
GO:0001525 (angiogenesis)
GO:0001890 (placenta development)
GO:0002062 (chondrocyte differentiation)
GO:0006006 (glucose metabolic process)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006357 (regulation of transcription from RNA polymerase II promoter)
GO:0006468 (protein phosphorylation)
GO:0006915 (apoptotic process)
GO:0006928 (movement of cell or subcellular component)
GO:0006935 (chemotaxis)
GO:0006974 (cellular response to DNA damage stimulus)
GO:0007165 (signal transduction)
GO:0007166 (cell surface receptor signaling pathway)
GO:0007178 (transmembrane receptor protein serine/threonine kinase signaling pathway)
GO:0007265 (Ras protein signal transduction)
GO:0007519 (skeletal muscle tissue development)
GO:0009749 (response to glucose)
GO:0010628 (positive regulation of gene expression)
GO:0010831 (positive regulation of myotube differentiation)
GO:0014835 (myoblast differentiation involved in skeletal muscle regeneration)
GO:0016310 (phosphorylation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0019395 (fatty acid oxidation)
GO:0030316 (osteoclast differentiation)
GO:0031281 (positive regulation of cyclase activity)
GO:0031663 (lipopolysaccharide-mediated signaling pathway)
GO:0032495 (response to muramyl dipeptide)
GO:0032496 (response to lipopolysaccharide)
GO:0035556 (intracellular signal transduction)
GO:0035924 (cellular response to vascular endothelial growth factor stimulus)
GO:0035994 (response to muscle stretch)
GO:0038066 (p38MAPK cascade)
GO:0042307 (positive regulation of protein import into nucleus)
GO:0042770 (signal transduction in response to DNA damage)
GO:0043536 (positive regulation of blood vessel endothelial cell migration)
GO:0045648 (positive regulation of erythrocyte differentiation)
GO:0045663 (positive regulation of myoblast differentiation)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0046326 (positive regulation of glucose import)
GO:0046777 (protein autophosphorylation)
GO:0048010 (vascular endothelial growth factor receptor signaling pathway)
GO:0051090 (regulation of sequence-specific DNA binding transcription factor activity)
GO:0051146 (striated muscle cell differentiation)
GO:0051149 (positive regulation of muscle cell differentiation)
GO:0051403 (stress-activated MAPK cascade)
GO:0060045 (positive regulation of cardiac muscle cell proliferation)
GO:0070935 (3'-UTR-mediated mRNA stabilization)
GO:0071222 (cellular response to lipopolysaccharide)
GO:0071479 (cellular response to ionizing radiation)
GO:0090090 (negative regulation of canonical Wnt signaling pathway)
GO:0090336 (positive regulation of brown fat cell differentiation)
GO:0090400 (stress-induced premature senescence)
GO:0098586 (cellular response to virus)
GO:1900015 (regulation of cytokine production involved in inflammatory response)
GO:1901741 (positive regulation of myoblast fusion)
GO:1901796 (regulation of signal transduction by p53 class mediator)
GO:2000379 (positive regulation of reactive oxygen species metabolic process)
GO:2001184 (positive regulation of interleukin-12 secretion)
Wikipedia MAPK14

Target Cross References - Protein

canSAR Q16539
Human Protein Atlas ENSG00000112062
IntAct Q16539
Guide to Pharmacology 1499
Open Targets ENSG00000112062
PharmGKB PA30621
Pharos Q16539 (Tchem)
Reactome R-HSA-168638 (NOD1/2 Signaling Pathway.)
R-HSA-171007 (p38MAPK events.)
R-HSA-198753 (ERK/MAPK targets.)
R-HSA-2151209 (Activation of PPARGC1A (PGC-1alpha) by phosphorylation.)
R-HSA-2559580 (Oxidative Stress Induced Senescence.)
R-HSA-375170 (CDO in myogenesis.)
R-HSA-376172 (DSCAM interactions.)
R-HSA-418592 (ADP signalling through P2Y purinoceptor 1.)
R-HSA-432142 (Platelet sensitization by LDL.)
R-HSA-4420097 (VEGFA-VEGFR2 Pathway.)
R-HSA-450302 (activated TAK1 mediates p38 MAPK activation.)
R-HSA-450341 (Activation of the AP-1 family of transcription factors.)
R-HSA-450604 (KSRP (KHSRP) binds and destabilizes mRNA.)
R-HSA-6798695 (Neutrophil degranulation.)
R-HSA-6804756 (Regulation of TP53 Activity through Phosphorylation.)
UniProt A6ZJ92 A8K6P4 B0LPH0 B5TY32 O60776 Q13083 Q14084 Q16539 Q8TDX0

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR003527 (MAP_kinase_CS.)
IPR008352 (MAPK_p38.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 1A9U 1BL6 1BL7 1BMK 1DI9 1IAN 1KV1 1KV2 1M7Q 1OUK 1OUY 1OVE 1OZ1 1R39 1R3C 1W7H 1W82 1W83 1W84 1WBN 1WBO 1WBS 1WBT 1WBV More...
CREDO 1A9U 1BL6 1BL7 1BMK 1DI9 1IAN 1KV1 1KV2 1M7Q 1OUK 1OUY 1OVE 1OZ1 1R39 1R3C 1W7H 1W82 1W83 1W84 1WBN 1WBO 1WBS 1WBT 1WBV More...
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