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Target Report Card

Target Name and Classification

Target ID CHEMBL2599
Target Type SINGLE PROTEIN
Preferred Name Tyrosine-protein kinase SYK
Synonyms SYK | Spleen tyrosine kinase | Tyrosine-protein kinase SYK | p72-Syk
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase syk family

Target Components

Component Description Relationship Accession
Tyrosine-protein kinase SYK SINGLE PROTEIN P43405

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2103830 FOSTAMATINIB Tyrosine-protein kinase SYK inhibitor 3 PubMed
CHEMBL475251 TAMATINIB Tyrosine-protein kinase SYK inhibitor 2 PubMed
CHEMBL3265032 ENTOSPLETINIB Tyrosine-protein kinase SYK inhibitor 2 PubMed
CHEMBL3545159 R-333 Tyrosine-protein kinase SYK inhibitor 2
CHEMBL3545284 Cerdulatinib Tyrosine-protein kinase SYK inhibitor 2 Other PubMed
CHEMBL3545340 R-343 Tyrosine-protein kinase SYK inhibitor 2
CHEMBL3545399 R-112 Tyrosine-protein kinase SYK inhibitor 2 PubMed
CHEMBL3544931 TAK-659 Tyrosine-protein kinase SYK inhibitor 1 Other Other
CHEMBL3545138 PRT-2607 Tyrosine-protein kinase SYK inhibitor 1 PubMed PubMed
CHEMBL3545301 HMPL-523 Tyrosine-protein kinase SYK inhibitor 1 Other Other
CHEMBL3545382 R-348 Tyrosine-protein kinase SYK inhibitor 1
More...

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000165025
Ensembl ENSG00000165025
GO Cellular Component GO:0005829 (cytosol)
GO:0005634 (nucleus)
GO:0042101 (T cell receptor complex)
GO:0019815 (B cell receptor complex)
GO:0043234 (protein complex)
GO:0005737 (cytoplasm)
GO:0031234 (extrinsic component of cytoplasmic side of plasma membrane)
GO:0032009 (early phagosome)
GO:0005886 (plasma membrane)
GO Molecular Function GO:0004716 (receptor signaling protein tyrosine kinase activity)
GO:0005178 (integrin binding)
GO:0004715 (non-membrane spanning protein tyrosine kinase activity)
GO:0005524 (ATP binding)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004672 (protein kinase activity)
GO Biological Process GO:0045425 (positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process)
GO:0051090 (regulation of sequence-specific DNA binding transcription factor activity)
GO:0090330 (regulation of platelet aggregation)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0007257 (activation of JUN kinase activity)
GO:0007596 (blood coagulation)
GO:0009887 (organ morphogenesis)
GO:0010543 (regulation of platelet activation)
GO:0016032 (viral process)
GO:0046641 (positive regulation of alpha-beta T cell proliferation)
GO:0048514 (blood vessel morphogenesis)
GO:0050850 (positive regulation of calcium-mediated signaling)
GO:0002554 (serotonin secretion by platelet)
GO:0006468 (protein phosphorylation)
GO:0010803 (regulation of tumor necrosis factor-mediated signaling pathway)
GO:0030168 (platelet activation)
GO:0033630 (positive regulation of cell adhesion mediated by integrin)
GO:0070372 (regulation of ERK1 and ERK2 cascade)
GO:0071226 (cellular response to molecule of fungal origin)
GO:0001945 (lymph vessel development)
GO:0002366 (leukocyte activation involved in immune response)
GO:0038095 (Fc-epsilon receptor signaling pathway)
GO:0038096 (Fc-gamma receptor signaling pathway involved in phagocytosis)
GO:0045579 (positive regulation of B cell differentiation)
GO:0002281 (macrophage activation involved in immune response)
GO:0007229 (integrin-mediated signaling pathway)
GO:0019370 (leukotriene biosynthetic process)
GO:0043313 (regulation of neutrophil degranulation)
GO:0045087 (innate immune response)
GO:0045401 (positive regulation of interleukin-3 biosynthetic process)
GO:0050731 (positive regulation of peptidyl-tyrosine phosphorylation)
GO:0050853 (B cell receptor signaling pathway)
GO:0002092 (positive regulation of receptor internalization)
GO:0002283 (neutrophil activation involved in immune response)
GO:0007159 (leukocyte cell-cell adhesion)
GO:0030154 (cell differentiation)
GO:0032481 (positive regulation of type I interferon production)
GO:0032928 (regulation of superoxide anion generation)
GO:0042991 (transcription factor import into nucleus)
GO:0090237 (regulation of arachidonic acid secretion)
GO:0001525 (angiogenesis)
GO:0002223 (stimulatory C-type lectin receptor signaling pathway)
GO:0002250 (adaptive immune response)
GO:0008283 (cell proliferation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0038083 (peptidyl-tyrosine autophosphorylation)
GO:0042742 (defense response to bacterium)
GO:0043306 (positive regulation of mast cell degranulation)
GO:0046638 (positive regulation of alpha-beta T cell differentiation)
GO:0050764 (regulation of phagocytosis)
GO:0030593 (neutrophil chemotaxis)
GO:0043366 (beta selection)
GO:0045588 (positive regulation of gamma-delta T cell differentiation)
GO:0045780 (positive regulation of bone resorption)
GO:0050715 (positive regulation of cytokine secretion)
Wikipedia Syk

Target Cross References - Protein

canSAR P43405
Human Protein Atlas ENSG00000165025
IntAct P43405
Guide to Pharmacology 2230 (spleen tyrosine kinase)
PharmGKB PA36273
UniProt P43405

Target Cross References - Domain

InterPro IPR000980 (SH2.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR000719 (Prot_kinase_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_kinase_cat_dom.)
IPR023420 (Kinase_SYK/ZAP-70_inter-SH2.)
IPR008266 (Tyr_kinase_AS.)
IPR012234 (Tyr_kinase_non-rcpt_SYK/ZAP70.)
IPR011009 (Kinase-like_dom.)
Pfam PF07714 (Pkinase_Tyr)
PF00017 (SH2)

Target Cross References - Structure

PDBe 3FQS 4I0S 4PV0 4RX8 4YJQ 4YJR 4YJT 1XBB 3VF8 4FL2 4FYO 4YJV 1A81 1XBC 3BUW 3EMG 4F4P 4RX7 4YJP 1XBA 3TUC 4FZ6 4PX6 4YJU More...
CREDO 3FQS 4I0S 4PV0 4RX8 4YJQ 4YJR 4YJT 1XBB 3VF8 4FL2 4FYO 4YJV 1A81 1XBC 3BUW 3EMG 4F4P 4RX7 4YJP 1XBA 3TUC 4FZ6 4PX6 4YJU More...
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