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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2599
Target Type SINGLE PROTEIN
Preferred Name Tyrosine-protein kinase SYK
Synonyms SYK | Spleen tyrosine kinase | Tyrosine-protein kinase SYK | p72-Syk
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase syk family

Target Components

Component Description Relationship Accession
Tyrosine-protein kinase SYK SINGLE PROTEIN P43405

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2103830 FOSTAMATINIB Tyrosine-protein kinase SYK inhibitor 3 PubMed
CHEMBL475251 TAMATINIB Tyrosine-protein kinase SYK inhibitor 2 PubMed
CHEMBL3265032 ENTOSPLETINIB Tyrosine-protein kinase SYK inhibitor 2 PubMed
CHEMBL3545159 R-333 Tyrosine-protein kinase SYK inhibitor 2
CHEMBL3545284 Cerdulatinib Tyrosine-protein kinase SYK inhibitor 2 Other PubMed
CHEMBL3545340 R-343 Tyrosine-protein kinase SYK inhibitor 2
CHEMBL3545399 R-112 Tyrosine-protein kinase SYK inhibitor 2 PubMed
CHEMBL3544931 TAK-659 Tyrosine-protein kinase SYK inhibitor 1 Other Other
CHEMBL3545138 PRT-2607 Tyrosine-protein kinase SYK inhibitor 1 PubMed PubMed
CHEMBL3545301 HMPL-523 Tyrosine-protein kinase SYK inhibitor 1 Other Other
CHEMBL3545382 R-348 Tyrosine-protein kinase SYK inhibitor 1
More...

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000165025
Ensembl ENSG00000165025
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0019815 (B cell receptor complex)
GO:0031234 (extrinsic component of cytoplasmic side of plasma membrane)
GO:0032009 (early phagosome)
GO:0042101 (T cell receptor complex)
GO:0043234 (protein complex)
GO Molecular Function GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004715 (non-membrane spanning protein tyrosine kinase activity)
GO:0004716 (receptor signaling protein tyrosine kinase activity)
GO:0005178 (integrin binding)
GO:0005524 (ATP binding)
GO Biological Process GO:0001525 (angiogenesis)
GO:0001945 (lymph vessel development)
GO:0002092 (positive regulation of receptor internalization)
GO:0002223 (stimulatory C-type lectin receptor signaling pathway)
GO:0002250 (adaptive immune response)
GO:0002281 (macrophage activation involved in immune response)
GO:0002283 (neutrophil activation involved in immune response)
GO:0002366 (leukocyte activation involved in immune response)
GO:0002554 (serotonin secretion by platelet)
GO:0006461 (protein complex assembly)
GO:0006468 (protein phosphorylation)
GO:0007159 (leukocyte cell-cell adhesion)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0007229 (integrin-mediated signaling pathway)
GO:0007257 (activation of JUN kinase activity)
GO:0007596 (blood coagulation)
GO:0008283 (cell proliferation)
GO:0009887 (organ morphogenesis)
GO:0010543 (regulation of platelet activation)
GO:0010803 (regulation of tumor necrosis factor-mediated signaling pathway)
GO:0016032 (viral process)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0019370 (leukotriene biosynthetic process)
GO:0030154 (cell differentiation)
GO:0030168 (platelet activation)
GO:0030593 (neutrophil chemotaxis)
GO:0032481 (positive regulation of type I interferon production)
GO:0032928 (regulation of superoxide anion generation)
GO:0033630 (positive regulation of cell adhesion mediated by integrin)
GO:0038083 (peptidyl-tyrosine autophosphorylation)
GO:0038095 (Fc-epsilon receptor signaling pathway)
GO:0038096 (Fc-gamma receptor signaling pathway involved in phagocytosis)
GO:0042742 (defense response to bacterium)
GO:0042991 (transcription factor import into nucleus)
GO:0043306 (positive regulation of mast cell degranulation)
GO:0043313 (regulation of neutrophil degranulation)
GO:0043366 (beta selection)
GO:0044419 (interspecies interaction between organisms)
GO:0045087 (innate immune response)
GO:0045401 (positive regulation of interleukin-3 biosynthetic process)
GO:0045425 (positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process)
GO:0045579 (positive regulation of B cell differentiation)
GO:0045588 (positive regulation of gamma-delta T cell differentiation)
GO:0045780 (positive regulation of bone resorption)
GO:0046638 (positive regulation of alpha-beta T cell differentiation)
GO:0046641 (positive regulation of alpha-beta T cell proliferation)
GO:0048514 (blood vessel morphogenesis)
GO:0050715 (positive regulation of cytokine secretion)
GO:0050731 (positive regulation of peptidyl-tyrosine phosphorylation)
GO:0050764 (regulation of phagocytosis)
GO:0050850 (positive regulation of calcium-mediated signaling)
GO:0050853 (B cell receptor signaling pathway)
GO:0051090 (regulation of sequence-specific DNA binding transcription factor activity)
GO:0070372 (regulation of ERK1 and ERK2 cascade)
GO:0071226 (cellular response to molecule of fungal origin)
GO:0090237 (regulation of arachidonic acid secretion)
GO:0090330 (regulation of platelet aggregation)
Wikipedia Syk

Target Cross References - Protein

canSAR P43405
Human Protein Atlas ENSG00000165025
IntAct P43405
PharmGKB PA36273
UniProt P43405

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_cat_dom.)
IPR000719 (Prot_kinase_dom.)
IPR000980 (SH2.)
IPR001245 (Ser-Thr/Tyr-Pkinase.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR008266 (Tyr_kinase_AS.)
IPR008266 (Tyr_prot_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR012234 (Tyr_kinase_non-rcpt_SYK/ZAP70.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_Pkinase_cat_dom.)
IPR020635 (Tyr_kinase_cat_dom.)
IPR023420 (Kinase_SYK/ZAP-70_inter-SH2.)
Pfam PF00017 (SH2)
PF07714 (Pkinase_Tyr)

Target Cross References - Structure

PDBe 1A81 1XBA 1XBB 1XBC 3BUW 3EMG 3FQE 3FQH 3FQS 3SRV 3TUB 3TUC 3TUD 3VF8 3VF9 4DFL 4DFN 4F4P 4FL1 4FL2 4FL3 4FYN 4FYO 4FZ6 More...
CREDO 1A81 1XBA 1XBB 1XBC 3BUW 3EMG 3FQE 3FQH 3FQS 3SRV 3TUB 3TUC 3TUD 3VF8 3VF9 4DFL 4DFN 4F4P 4FL1 4FL2 4FL3 4FYN 4FYO 4FZ6 More...
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