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Target Report Card

Target Name and Classification

Target ID CHEMBL2598
Preferred Name Protein kinase C iota
Synonyms Atypical protein kinase C-lambda/iota | DXS1179E | PRKC-lambda/iota | PRKCI | Protein kinase C iota type | aPKC-lambda/iota | nPKC-iota
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > agc protein kinase group > agc protein kinase pkc family > agc protein kinase pkc iota subfamily

Target Components

Component Description Relationship Accession
Protein kinase C iota type SINGLE PROTEIN P41743

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2093867 Protein kinase C (PKC) PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000163558
Ensembl ENSG00000163558
GO Cellular Component GO:0000139 (Golgi membrane)
GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005768 (endosome)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005923 (bicellular tight junction)
GO:0015630 (microtubule cytoskeleton)
GO:0016020 (membrane)
GO:0016324 (apical plasma membrane)
GO:0031252 (cell leading edge)
GO:0043220 (Schmidt-Lanterman incisure)
GO:0043234 (protein complex)
GO:0045171 (intercellular bridge)
GO:0045177 (apical part of cell)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004697 (protein kinase C activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0005543 (phospholipid binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0019904 (protein domain specific binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0006612 (protein targeting to membrane)
GO:0007010 (cytoskeleton organization)
GO:0007015 (actin filament organization)
GO:0010976 (positive regulation of neuron projection development)
GO:0016192 (vesicle-mediated transport)
GO:0016310 (phosphorylation)
GO:0016477 (cell migration)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0032869 (cellular response to insulin stimulus)
GO:0034351 (negative regulation of glial cell apoptotic process)
GO:0034613 (cellular protein localization)
GO:0035089 (establishment of apical/basal cell polarity)
GO:0035556 (intracellular signal transduction)
GO:0042462 (eye photoreceptor cell development)
GO:0043066 (negative regulation of apoptotic process)
GO:0043434 (response to peptide hormone)
GO:0043524 (negative regulation of neuron apoptotic process)
GO:0045197 (establishment or maintenance of epithelial cell apical/basal polarity)
GO:0045216 (cell-cell junction organization)
GO:0046326 (positive regulation of glucose import)
GO:0046903 (secretion)
GO:0048194 (Golgi vesicle budding)
GO:0051092 (positive regulation of NF-kappaB transcription factor activity)
GO:0060252 (positive regulation of glial cell proliferation)
GO:0061024 (membrane organization)
GO:0070555 (response to interleukin-1)
GO:0070830 (bicellular tight junction assembly)
GO:0090004 (positive regulation of establishment of protein localization to plasma membrane)
GO:2000353 (positive regulation of endothelial cell apoptotic process)
Wikipedia PRKCI

Target Cross References - Protein

canSAR P41743
Human Protein Atlas ENSG00000163558
IntAct P41743
Guide to Pharmacology 1490
Open Targets ENSG00000163558
PharmGKB PA33768
Pharos P41743 (Tbio)
Reactome R-HSA-209543 (p75NTR recruits signalling complexes.)
R-HSA-420029 (Tight junction interactions.)
UniProt D3DNQ4 P41743 Q8WW06

Target Cross References - Domain

InterPro IPR000270 (PB1_dom.)
IPR000719 (Prot_kinase_dom.)
IPR000961 (AGC-kinase_C.)
IPR002219 (PE/DAG-bd.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR012233 (PKC.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR017892 (Pkinase_C.)
IPR020454 (DAG/PE-bd.)
Pfam PF00069 (Pkinase)
PF00130 (C1_1)
PF00433 (Pkinase_C)
PF00564 (PB1)

Target Cross References - Structure

PDBe 1WMH 1ZRZ 3A8W 3A8X 3ZH8 5LI1 5LI9 5LIH