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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2598
Target Type SINGLE PROTEIN
Preferred Name Protein kinase C iota
Synonyms Atypical protein kinase C-lambda/iota | DXS1179E | PRKC-lambda/iota | PRKCI | Protein kinase C iota type | aPKC-lambda/iota | nPKC-iota
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > agc protein kinase group > agc protein kinase pkc family > agc protein kinase pkc iota subfamily

Target Components

Component Description Relationship Accession
Protein kinase C iota type SINGLE PROTEIN P41743

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2093867 Protein kinase C (PKC) PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000163558
Ensembl ENSG00000163558
GO Cellular Component GO:0000133 (polarisome)
GO:0005634 (nucleus)
GO:0005768 (endosome)
GO:0005829 (cytosol)
GO Molecular Function GO:0004697 (protein kinase C activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0005543 (phospholipid binding)
GO:0008270 (zinc ion binding)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0006612 (protein targeting to membrane)
GO:0006916 (anti-apoptosis)
GO:0016044 (cellular membrane organization)
GO:0016192 (vesicle-mediated transport)
GO:0032869 (cellular response to insulin stimulus)
GO:0035556 (intracellular signal transduction)
GO:0045197 (establishment or maintenance of epithelial cell apical/basal polarity)
GO:0046326 (positive regulation of glucose import)
GO:0046903 (secretion)
GO:0048011 (nerve growth factor receptor signaling pathway)
GO:0070830 (tight junction assembly)
GO:0090004 (positive regulation of establishment of protein localization in plasma membrane)
Wikipedia PRKCI

Target Cross References - Protein

canSAR P41743
Human Protein Atlas ENSG00000163558
IntAct P41743
Guide to Pharmacology 1490 (protein kinase C, iota)
PharmGKB PA33768
Reactome REACT_11061 (Signalling by NGF.)
REACT_20676 (Cell junction organization.)
UniProt D3DNQ4 P41743 Q8WW06

Target Cross References - Domain

InterPro IPR000270 (OPR_PB1.)
IPR000719 (Prot_kinase_cat_dom.)
IPR000961 (AGC-kinase_C.)
IPR002219 (Prot_Kinase_C-like_PE/DAG-bd.)
IPR002290 (Ser/Thr_prot_kinase_dom.)
IPR008271 (Ser/Thr_prot_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR012233 (PKC_zeta.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR017442 (Se/Thr_prot_kinase-like_dom.)
IPR017892 (Pkinase_C.)
IPR020454 (DAG/PE-bd.)
Pfam PF00069 (Pkinase)
PF00130 (C1_1)
PF00433 (Pkinase_C)
PF00564 (PB1)

Target Cross References - Structure

PDBe 1WMH 1ZRZ 3A8W 3A8X
CREDO 1WMH 1ZRZ 3A8W 3A8X
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