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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2582
Target Type SINGLE PROTEIN
Preferred Name Cyclin A2
Synonyms CCN1 | CCNA | CCNA2 | Cyclin A | Cyclin-A | Cyclin-A2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • other cytosolic protein

Target Components

Component Description Relationship Accession
Cyclin-A2 SINGLE PROTEIN P20248

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3038467 CDK1/Cyclin A PROTEIN COMPLEX
CHEMBL3038469 CDK2/Cyclin A PROTEIN COMPLEX
CHEMBL2094128 Cyclin-dependent kinase 2/cyclin A PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000145386
Ensembl ENSG00000145386
GO Cellular Component GO:0001939 (female pronucleus)
GO:0001940 (male pronucleus)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005794 (Golgi apparatus)
GO Molecular Function GO:0005515 (protein binding)
GO:0019901 (protein kinase binding)
GO Biological Process GO:0000079 (regulation of cyclin-dependent protein serine/threonine kinase activity)
GO:0007049 (cell cycle)
GO:0007067 (mitotic nuclear division)
GO:0007095 (mitotic G2 DNA damage checkpoint)
GO:0007265 (Ras protein signal transduction)
GO:0010389 (regulation of G2/M transition of mitotic cell cycle)
GO:0016032 (viral process)
GO:0031100 (organ regeneration)
GO:0032355 (response to estradiol)
GO:0033762 (response to glucagon)
GO:0036120 (cellular response to platelet-derived growth factor stimulus)
GO:0044320 (cellular response to leptin stimulus)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0048146 (positive regulation of fibroblast proliferation)
GO:0051301 (cell division)
GO:0071314 (cellular response to cocaine)
GO:0071373 (cellular response to luteinizing hormone stimulus)
GO:0071392 (cellular response to estradiol stimulus)
GO:0071407 (cellular response to organic cyclic compound)
GO:0071456 (cellular response to hypoxia)
GO:0071732 (cellular response to nitric oxide)
GO:0090102 (cochlea development)
GO:1990314 (cellular response to insulin-like growth factor stimulus)
Wikipedia Cyclin_A2

Target Cross References - Protein

Human Protein Atlas ENSG00000145386
IntAct P20248
Open Targets ENSG00000145386
PharmGKB PA94
Reactome R-HSA-1538133 (G0 and Early G1.)
R-HSA-170145 (Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes.)
R-HSA-174184 (Cdc20:Phospho-APC/C mediated degradation of Cyclin A.)
R-HSA-176408 (Regulation of APC/C activators between G1/S and early anaphase.)
R-HSA-187577 (SCF(Skp2)-mediated degradation of p27/p21.)
R-HSA-2559582 (Senescence-Associated Secretory Phenotype (SASP).)
R-HSA-2559586 (DNA Damage/Telomere Stress Induced Senescence.)
R-HSA-5689880 (Ub-specific processing proteases.)
R-HSA-5693607 (Processing of DNA double-strand break ends.)
R-HSA-6804116 (TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest.)
R-HSA-6804756 (Regulation of TP53 Activity through Phosphorylation.)
R-HSA-6804757 (Regulation of TP53 Degradation.)
R-HSA-68911 (G2 Phase.)
R-HSA-68949 (Orc1 removal from chromatin.)
R-HSA-69273 (Cyclin A/B1 associated events during G2/M transition.)
R-HSA-69563 (p53-Dependent G1 DNA Damage Response.)
R-HSA-69656 (Cyclin A:Cdk2-associated events at S phase entry.)
UniProt A8K7B6 P20248 Q2M3U6 Q4W5P4 Q6LER8

Target Cross References - Domain

InterPro IPR004367 (Cyclin_C-dom.)
IPR006671 (Cyclin_N.)
IPR013763 (Cyclin-like.)
IPR015453 (Cyclin_A2_chordates.)
IPR032447 (Cyclin-A_N.)
Pfam PF00134 (Cyclin_N)
PF02984 (Cyclin_C)
PF16500 (Cyclin_N2)

Target Cross References - Structure

PDBe 1E9H 1FIN 1FVV 1GY3 1H1P 1H1Q 1H1R 1H1S 1H24 1H25 1H26 1H27 1H28 1JST 1JSU 1OGU 1OI9 1OIU 1OIY 1OKV 1OKW 1OL1 1OL2 1P5E More...
CREDO 1E9H 1FIN 1FVV 1GY3 1H1P 1H1Q 1H1R 1H1S 1H24 1H25 1H26 1H27 1H28 1JST 1JSU 1OGU 1OI9 1OIU 1OIY 1OKV 1OKW 1OL1 1OL2 1P5E More...
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