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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2582
Target Type SINGLE PROTEIN
Preferred Name Cyclin A2
Synonyms CCN1 | CCNA | CCNA2 | Cyclin-A | Cyclin-A2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • other cytosolic protein

Target Components

Component Description Relationship Accession
Cyclin-A2 SINGLE PROTEIN P20248

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3038469 CDK2/Cyclin A PROTEIN COMPLEX
CHEMBL3038467 CDK1/Cyclin A PROTEIN COMPLEX
CHEMBL2094128 Cyclin-dependent kinase 2/cyclin A PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000145386
Ensembl ENSG00000145386
GO Cellular Component GO:0001939 (female pronucleus)
GO:0005654 (nucleoplasm)
GO:0005794 (Golgi apparatus)
GO:0005634 (nucleus)
GO:0001940 (male pronucleus)
GO:0005737 (cytoplasm)
GO Biological Process GO:0007265 (Ras protein signal transduction)
GO:0016032 (viral process)
GO:0031100 (organ regeneration)
GO:0033762 (response to glucagon)
GO:0000278 (mitotic cell cycle)
GO:0032355 (response to estradiol)
GO:0000079 (regulation of cyclin-dependent protein serine/threonine kinase activity)
GO:0000086 (G2/M transition of mitotic cell cycle)
GO:0007095 (mitotic G2 DNA damage checkpoint)
GO:0048146 (positive regulation of fibroblast proliferation)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0051301 (cell division)
GO:0007067 (mitotic nuclear division)
Wikipedia Cyclin_A2

Target Cross References - Protein

Human Protein Atlas ENSG00000145386
IntAct P20248
PharmGKB PA94
UniProt Q2M3U6 A8K7B6 P20248 Q4W5P4 Q6LER8

Target Cross References - Domain

InterPro IPR006671 (Cyclin_N.)
IPR013763 (Cyclin-like.)
IPR015453 (Cyclin_A2_chordates.)
IPR004367 (Cyclin_C-dom.)
IPR032447 (Cyclin-A_N.)
Pfam PF02984 (Cyclin_C)
PF00134 (Cyclin_N)
PF16500 (Cyclin_N2)

Target Cross References - Structure

PDBe 1OL2 2CCH 2UZB 2WPA 4BCN 4CFV 1H1Q 1H25 2BPM 2C4G 2CJM 2IW6 2IW8 2WXV 2X1N 3EID 4BCP 4CFM 4EOK 4EOP 1FVV 1H28 1JSU 1OI9 More...
CREDO 1OL2 2CCH 2UZB 2WPA 4BCN 4CFV 1H1Q 1H25 2BPM 2C4G 2CJM 2IW6 2IW8 2WXV 2X1N 3EID 4BCP 4CFM 4EOK 4EOP 1FVV 1H28 1JSU 1OI9 More...
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