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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2581
Target Type SINGLE PROTEIN
Preferred Name Cathepsin D
Synonyms CPSD | CTSD | Cathepsin D | Cathepsin D heavy chain | Cathepsin D light chain
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > aspartic protease > aspartic protease aa clan > aspartic protease a1a subfamily

Target Components

Component Description Relationship Accession
Cathepsin D SINGLE PROTEIN P07339

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000117984
Ensembl ENSG00000117984
GO Cellular Component GO:0005615 (extracellular space)
GO:0005764 (lysosome)
GO:0042470 (melanosome)
GO Molecular Function GO:0004190 (aspartic-type endopeptidase activity)
GO Biological Process GO:0006508 (proteolysis)
GO:0008219 (cell death)
Wikipedia Cathepsin_D

Target Cross References - Protein

canSAR P07339
CGD Ceroid lipofuscinosis, neuronal, 10
Human Protein Atlas ENSG00000117984
IntAct P07339
Guide to Pharmacology 2345 (cathepsin D)
PharmGKB PA27029
UniProt P07339 Q6IB57

Target Cross References - Domain

InterPro IPR001461 (Peptidase_A1.)
IPR001969 (Peptidase_aspartic_AS.)
IPR009007 (Peptidase_aspartic_catalytic.)
IPR012848 (Propep_A1.)
IPR021109 (Peptidase_aspartic.)
Pfam PF00026 (Asp)
PF07966 (A1_Propeptide)

Target Cross References - Structure

PDBe 1LYA 1LYB 1LYW
CREDO 1LYA 1LYB 1LYW
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