ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL2581
Target Type SINGLE PROTEIN
Preferred Name Cathepsin D
Synonyms CPSD | CTSD | Cathepsin D heavy chain | Cathepsin D light chain | Cathepsin D
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > aspartic protease > aspartic protease aa clan > aspartic protease a1a subfamily

Target Components

Component Description Relationship Accession
Cathepsin D SINGLE PROTEIN P07339

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000117984
Ensembl ENSG00000117984
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005764 (lysosome)
GO:0031012 (extracellular matrix)
GO:0042470 (melanosome)
GO:0043202 (lysosomal lumen)
GO:0045121 (membrane raft)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004190 (aspartic-type endopeptidase activity)
GO:0004197 (cysteine-type endopeptidase activity)
GO:0004252 (serine-type endopeptidase activity)
GO:0005515 (protein binding)
GO:0008233 (peptidase activity)
GO:0016787 (hydrolase activity)
GO Biological Process GO:0006508 (proteolysis)
GO:0006914 (autophagy)
GO:0019886 (antigen processing and presentation of exogenous peptide antigen via MHC class II)
GO:0030163 (protein catabolic process)
GO:0030574 (collagen catabolic process)
Wikipedia Cathepsin_D

Target Cross References - Protein

canSAR P07339
CGD Ceroid lipofuscinosis, neuronal, 10
Human Protein Atlas ENSG00000117984
IntAct P07339
Guide to Pharmacology 2345
Open Targets ENSG00000117984
PharmGKB PA27029
Reactome R-HSA-1442490 (Collagen degradation.)
R-HSA-2022377 (Metabolism of Angiotensinogen to Angiotensins.)
R-HSA-2132295 (MHC class II antigen presentation.)
UniProt P07339 Q6IB57

Target Cross References - Domain

InterPro IPR001461 (Aspartic_peptidase_A1.)
IPR001969 (Aspartic_peptidase_AS.)
IPR012848 (Aspartic_peptidase_N.)
IPR021109 (Peptidase_aspartic_dom.)
IPR033121 (PEPTIDASE_A1.)
IPR033144 (Cathepsin_D.)
Pfam PF00026 (Asp)
PF07966 (A1_Propeptide)

Target Cross References - Structure

PDBe 1LYA 1LYB 1LYW 4OBZ 4OC6 4OD9
CREDO 1LYA 1LYB 1LYW 4OBZ 4OC6 4OD9
spacer
spacer