ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL258
Target Type SINGLE PROTEIN
Preferred Name Tyrosine-protein kinase LCK
Synonyms LCK | LSK | Leukocyte C-terminal Src kinase | Lymphocyte cell-specific protein-tyrosine kinase | Protein YT16 | Proto-oncogene Lck | T cell-specific protein-tyrosine kinase | Tyrosine-protein kinase Lck | p56-LCK
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase src family

Target Components

Component Description Relationship Accession
Tyrosine-protein kinase Lck SINGLE PROTEIN P06239

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2363074 SRC PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1201733 PAZOPANIB HYDROCHLORIDE Tyrosine-protein kinase LCK inhibitor 4 DailyMed
CHEMBL3545133 JNJ-26483327 Tyrosine-protein kinase LCK inhibitor 1 DOI PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000182866
Ensembl ENSG00000182866
GO Cellular Component GO:0000242 (pericentriolar material)
GO:0001772 (immunological synapse)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0031234 (extrinsic component of cytoplasmic side of plasma membrane)
GO:0045121 (membrane raft)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0001948 (glycoprotein binding)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004715 (non-membrane spanning protein tyrosine kinase activity)
GO:0004722 (protein serine/threonine phosphatase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008022 (protein C-terminus binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0019901 (protein kinase binding)
GO:0019903 (protein phosphatase binding)
GO:0042169 (SH2 domain binding)
GO:0042609 (CD4 receptor binding)
GO:0042610 (CD8 receptor binding)
GO:0042802 (identical protein binding)
GO:0043548 (phosphatidylinositol 3-kinase binding)
GO:0046934 (phosphatidylinositol-4,5-bisphosphate 3-kinase activity)
GO:0051117 (ATPase binding)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0006470 (protein dephosphorylation)
GO:0006882 (cellular zinc ion homeostasis)
GO:0006919 (activation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0014066 (regulation of phosphatidylinositol 3-kinase signaling)
GO:0016032 (viral process)
GO:0016310 (phosphorylation)
GO:0030097 (hemopoiesis)
GO:0030168 (platelet activation)
GO:0030217 (T cell differentiation)
GO:0031295 (T cell costimulation)
GO:0038083 (peptidyl-tyrosine autophosphorylation)
GO:0042127 (regulation of cell proliferation)
GO:0042493 (response to drug)
GO:0045087 (innate immune response)
GO:0046854 (phosphatidylinositol phosphorylation)
GO:0048015 (phosphatidylinositol-mediated signaling)
GO:0050690 (regulation of defense response to virus by virus)
GO:0050852 (T cell receptor signaling pathway)
GO:0050853 (B cell receptor signaling pathway)
GO:0050862 (positive regulation of T cell receptor signaling pathway)
GO:0050870 (positive regulation of T cell activation)
GO:0050900 (leukocyte migration)
GO:0051209 (release of sequestered calcium ion into cytosol)
GO:0051249 (regulation of lymphocyte activation)
GO:2001244 (positive regulation of intrinsic apoptotic signaling pathway)
Wikipedia Lck

Target Cross References - Protein

canSAR P06239
Human Protein Atlas ENSG00000182866
IntAct P06239
Guide to Pharmacology 2053
Open Targets ENSG00000182866
PharmGKB PA30307
Pharos P06239 (Tclin)
Reactome R-HSA-114604 (GPVI-mediated activation cascade.)
R-HSA-1257604 (PIP3 activates AKT signaling.)
R-HSA-1433557 (Signaling by SCF-KIT.)
R-HSA-1433559 (Regulation of KIT signaling.)
R-HSA-164944 (Nef and signal transduction.)
R-HSA-167590 (Nef Mediated CD4 Down-regulation.)
R-HSA-202424 (Downstream TCR signaling.)
R-HSA-202427 (Phosphorylation of CD3 and TCR zeta chains.)
R-HSA-202430 (Translocation of ZAP-70 to Immunological synapse.)
R-HSA-202433 (Generation of second messenger molecules.)
R-HSA-210990 (PECAM1 interactions.)
R-HSA-2219530 (Constitutive Signaling by Aberrant PI3K in Cancer.)
R-HSA-2424491 (DAP12 signaling.)
R-HSA-389356 (CD28 co-stimulation.)
R-HSA-389357 (CD28 dependent PI3K/Akt signaling.)
R-HSA-389359 (CD28 dependent Vav1 pathway.)
R-HSA-389513 (CTLA4 inhibitory signaling.)
R-HSA-389948 (PD-1 signaling.)
R-HSA-451927 (Interleukin-2 signaling.)
R-HSA-6811558 (PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.)
UniProt D3DPP8 P06239 P07100 Q12850 Q13152 Q5TDH8 Q5TDH9 Q7RTZ3 Q96DW4 Q9NYT8

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR000980 (SH2.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR001452 (SH3_domain.)
IPR008266 (Tyr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_kinase_cat_dom.)
Pfam PF00017 (SH2)
PF00018 (SH3_1)
PF07714 (Pkinase_Tyr)

Target Cross References - Structure

PDBe 1BHF 1BHH 1CWD 1CWE 1FBZ 1IJR 1LCJ 1LCK 1LKK 1LKL 1QPC 1QPD 1QPE 1QPJ 1X27 2IIM 2OF2 2OF4 2OFU 2OFV 2OG8 2PL0 2ZM1 2ZM4 More...
CREDO 1BHF 1BHH 1CWD 1CWE 1FBZ 1IJR 1LCJ 1LCK 1LKK 1LKL 1QPC 1QPD 1QPE 1QPJ 1X27 2IIM 2OF2 2OF4 2OFU 2OFV 2OG8 2PL0 2ZM1 2ZM4 More...
spacer
spacer