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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2569
Target Type SINGLE PROTEIN
Preferred Name Microsomal triglyceride transfer protein large subunit
Synonyms MTP | MTTP | Microsomal triglyceride transfer protein large subunit
Organism Homo sapiens
Species Group No
Protein Target Classification
  • other cytosolic protein

Target Components

Component Description Relationship Accession
Microsomal triglyceride transfer protein large subunit SINGLE PROTEIN P55157

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2364681 Microsomal triglyceride transfer protein PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000138823
Ensembl ENSG00000138823
GO Cellular Component GO:0005783 (endoplasmic reticulum)
GO:0005788 (endoplasmic reticulum lumen)
GO:0043235 (receptor complex)
GO Molecular Function GO:0005319 (lipid transporter activity)
GO:0005515 (protein binding)
GO:0005548 (phospholipid transporter activity)
GO:0008289 (lipid binding)
GO:0046982 (protein heterodimerization activity)
GO Biological Process GO:0006629 (lipid metabolic process)
GO:0006810 (transport)
GO:0006869 (lipid transport)
GO:0015914 (phospholipid transport)
GO:0034197 (triglyceride transport)
GO:0034377 (plasma lipoprotein particle assembly)
GO:0042158 (lipoprotein biosynthetic process)
Wikipedia Microsomal_triglyceride_transfer_protein

Target Cross References - Protein

canSAR P55157
CGD Abetalipoproteinemia
Human Protein Atlas ENSG00000138823
IntAct P55157
Open Targets ENSG00000138823
PharmGKB PA164742099
Reactome R-HSA-174800 (Chylomicron-mediated lipid transport.)
R-HSA-8866423 (VLDL biosynthesis.)
UniProt A8K428 P55157 Q08AM4 Q6P5T3

Target Cross References - Domain

InterPro IPR001747 (Lipid_transpt_N.)
IPR011030 (Vitellinogen_superhlx.)
IPR015816 (Vitellinogen_b-sht_N.)
IPR015819 (Lipid_transp_b-sht_shell.)
Pfam PF01347 (Vitellogenin_N)
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