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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2569
Target Type SINGLE PROTEIN
Preferred Name Microsomal triglyceride transfer protein large subunit
Synonyms MTP | MTTP | Microsomal triglyceride transfer protein large subunit
Organism Homo sapiens
Species Group No
Protein Target Classification
  • other cytosolic protein

Target Components

Component Description Relationship Accession
Microsomal triglyceride transfer protein large subunit SINGLE PROTEIN P55157

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2364681 Microsomal triglyceride transfer protein PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000138823
Ensembl ENSG00000138823
GO Cellular Component GO:0005788 (endoplasmic reticulum lumen)
GO Molecular Function GO:0005319 (lipid transporter activity)
GO:0008289 (lipid binding)
GO Biological Process GO:0006629 (lipid metabolic process)
GO:0042157 (lipoprotein metabolic process)
Wikipedia Microsomal_triglyceride_transfer_protein

Target Cross References - Protein

canSAR P55157
CGD Abetalipoproteinemia
Human Protein Atlas ENSG00000138823
PharmGKB PA164742099
Reactome REACT_22258 (Metabolism of lipids and lipoproteins.)
UniProt A8K428 P55157 Q08AM4

Target Cross References - Domain

InterPro IPR001747 (Lipid_transpt_N.)
IPR011030 (Vitellinogen_superhlx.)
IPR015816 (Vitellinogen_b-sht_N.)
IPR015819 (Lipid_transp_b-sht_shell.)
Pfam PF01347 (Vitellogenin_N)
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