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Target Report Card

Target Name and Classification

Target ID CHEMBL2563
Preferred Name Histone deacetylase 5
Synonyms Antigen NY-CO-9 | HD5 | HDAC5 | Histone deacetylase 5 | KIAA0600
Organism Homo sapiens
Species Group No
Protein Target Classification
  • epigenetic regulator > eraser > histone deacetylase > hdac class iia

Target Components

Component Description Relationship Accession
Histone deacetylase 5 SINGLE PROTEIN Q9UQL6

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3038483 Histone deacetylase 1/3/5/8 PROTEIN FAMILY
CHEMBL2093865 Histone deacetylase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000108840
Ensembl ENSG00000108840
GO Cellular Component GO:0000118 (histone deacetylase complex)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005794 (Golgi apparatus)
GO:0005829 (cytosol)
GO:0016607 (nuclear speck)
GO:0032991 (macromolecular complex)
GO Molecular Function GO:0001047 (core promoter binding)
GO:0001085 (RNA polymerase II transcription factor binding)
GO:0003682 (chromatin binding)
GO:0004407 (histone deacetylase activity)
GO:0005080 (protein kinase C binding)
GO:0005515 (protein binding)
GO:0008134 (transcription factor binding)
GO:0016787 (hydrolase activity)
GO:0032041 (NAD-dependent histone deacetylase activity (H3-K14 specific))
GO:0033558 (protein deacetylase activity)
GO:0042826 (histone deacetylase binding)
GO:0044212 (transcription regulatory region DNA binding)
GO:0046872 (metal ion binding)
GO:0070491 (repressing transcription factor binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0006325 (chromatin organization)
GO:0006338 (chromatin remodeling)
GO:0006342 (chromatin silencing)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006476 (protein deacetylation)
GO:0006954 (inflammatory response)
GO:0010830 (regulation of myotube differentiation)
GO:0010832 (negative regulation of myotube differentiation)
GO:0014823 (response to activity)
GO:0016575 (histone deacetylation)
GO:0030182 (neuron differentiation)
GO:0030183 (B cell differentiation)
GO:0032869 (cellular response to insulin stimulus)
GO:0040029 (regulation of gene expression, epigenetic)
GO:0042113 (B cell activation)
GO:0042220 (response to cocaine)
GO:0042493 (response to drug)
GO:0043393 (regulation of protein binding)
GO:0045892 (negative regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0051091 (positive regulation of sequence-specific DNA binding transcription factor activity)
GO:0070932 (histone H3 deacetylation)
GO:0071222 (cellular response to lipopolysaccharide)
GO:0090051 (negative regulation of cell migration involved in sprouting angiogenesis)
GO:2000615 (regulation of histone H3-K9 acetylation)
Wikipedia Histone_deacetylase_5

Target Cross References - Protein

Human Protein Atlas ENSG00000108840
IntAct Q9UQL6
Guide to Pharmacology 2660
Open Targets ENSG00000108840
PharmGKB PA29230
Reactome R-HSA-2122947 (NOTCH1 Intracellular Domain Regulates Transcription.)
R-HSA-2644606 (Constitutive Signaling by NOTCH1 PEST Domain Mutants.)
R-HSA-2894862 (Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.)
R-HSA-8943724 (Regulation of PTEN gene transcription.)
UniProt C9JFV9 O60340 O60528 Q96DY4 Q9UQL6

Target Cross References - Domain

InterPro IPR000286 (His_deacetylse.)
IPR017320 (Histone_deAcase_II_euk.)
IPR023696 (Ureohydrolase_dom_sf.)
IPR023801 (His_deacetylse_dom.)
IPR024643 (Hist_deacetylase_Gln_rich_N.)
IPR030703 (Histone_deacetylase_5.)
IPR037138 (His_deacetylse_dom_sf.)
Pfam PF00850 (Hist_deacetyl)
PF12203 (HDAC4_Gln)

Target Cross References - Structure