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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL256
Target Type SINGLE PROTEIN
Preferred Name Adenosine A3 receptor
Synonyms ADORA3 | Adenosine receptor A3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > nucleotide-like receptor (family a gpcr) > adenosine receptor

Target Components

Component Description Relationship Accession
Adenosine receptor A3 SINGLE PROTEIN P33765

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095195 Adenosine receptors; A1 & A3 SELECTIVITY GROUP
CHEMBL2111329 Adenosine receptor PROTEIN FAMILY
CHEMBL2095213 Adenosine receptors; A2a & A3 SELECTIVITY GROUP
CHEMBL2095234 Adenosine receptors; A2b & A3 SELECTIVITY GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000121933
Ensembl ENSG00000121933
GO Cellular Component GO:0005887 (integral to plasma membrane)
GO Molecular Function GO:0001609 (adenosine receptor activity, G-protein coupled)
GO Biological Process GO:0006954 (inflammatory response)
GO:0007190 (activation of adenylate cyclase activity)
GO:0008016 (regulation of heart contraction)
Wikipedia Adenosine_A3_receptor

Target Cross References - Protein

canSAR P33765
Human Protein Atlas ENSG00000121933
Guide to Pharmacology 21 (A3)
PharmGKB PA24589
Reactome REACT_14797 (Signaling by GPCR.)
UniProt A2A3P4 P33765 Q6UWU0 Q9BYZ1

Target Cross References - Domain

InterPro IPR000276 (7TM_GPCR_Rhodpsn.)
IPR000466 (Adeno_A3_rcpt.)
IPR001634 (Adenosn_rcpt.)
IPR017452 (GPCR_Rhodpsn_supfam.)
Pfam PF00001 (7tm_1)
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