ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL2558
Target Type SINGLE PROTEIN
Preferred Name Death-associated protein kinase 1
Synonyms DAP kinase 1 | DAPK | DAPK1 | Death-associated protein kinase 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > camk protein kinase group > camk protein kinase dapk family

Target Components

Component Description Relationship Accession
Death-associated protein kinase 1 SINGLE PROTEIN P53355

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000196730
Ensembl ENSG00000196730
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005856 (cytoskeleton)
GO:0005886 (plasma membrane)
GO:0015629 (actin cytoskeleton)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004683 (calmodulin-dependent protein kinase activity)
GO:0005515 (protein binding)
GO:0005516 (calmodulin binding)
GO:0005524 (ATP binding)
GO:0005525 (GTP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0017075 (syntaxin-1 binding)
GO:0042802 (identical protein binding)
GO Biological Process GO:0006417 (regulation of translation)
GO:0006468 (protein phosphorylation)
GO:0006915 (apoptotic process)
GO:0007165 (signal transduction)
GO:0008625 (extrinsic apoptotic signaling pathway via death domain receptors)
GO:0010506 (regulation of autophagy)
GO:0016310 (phosphorylation)
GO:0017148 (negative regulation of translation)
GO:0035556 (intracellular signal transduction)
GO:0042981 (regulation of apoptotic process)
GO:0043066 (negative regulation of apoptotic process)
GO:0043280 (positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0046777 (protein autophosphorylation)
GO:0071346 (cellular response to interferon-gamma)
GO:0097190 (apoptotic signaling pathway)
GO:1902042 (negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)
GO:2000310 (regulation of N-methyl-D-aspartate selective glutamate receptor activity)
Wikipedia DAPK1

Target Cross References - Protein

Human Protein Atlas ENSG00000196730
IntAct P53355
Guide to Pharmacology 2002
Open Targets ENSG00000196730
PharmGKB PA27142
Pharos P53355 (Tchem)
Reactome R-HSA-418889 (Ligand-independent caspase activation via DCC.)
UniProt B7ZLD2 B7ZLE7 P53355 Q14CQ7 Q1W5W0 Q68CP8 Q6ZRZ3 Q9BTL8

Target Cross References - Domain

InterPro IPR000488 (Death_domain.)
IPR000719 (Prot_kinase_dom.)
IPR002110 (Ankyrin_rpt.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR011029 (DEATH-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020676 (DAPK1.)
IPR020683 (Ankyrin_rpt-contain_dom.)
IPR020859 (ROC_dom.)
IPR027417 (P-loop_NTPase.)
Pfam PF00069 (Pkinase)
PF00531 (Death)
PF12796 (Ank_2)

Target Cross References - Structure

PDBe 1IG1 1JKK 1JKL 1JKS 1JKT 1P4F 1WVW 1WVX 1WVY 1YR5 2W4J 2W4K 2X0G 2XUU 2XZS 2Y0A 2Y4P 2Y4V 2YAK 3DFC 3DGK 3EH9 3EHA 3F5G More...
CREDO 1IG1 1JKK 1JKL 1JKS 1JKT 1P4F 1WVW 1WVX 1WVY 1YR5 2W4J 2W4K 2X0G 2XUU 2XZS 2Y0A 2Y4P 2Y4V 2YAK 3DFC 3DGK 3EH9 3EHA 3F5G More...
spacer
spacer