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Target Report Card

Target Name and Classification

Target ID CHEMBL2553
Preferred Name Ribosomal protein S6 kinase alpha 1
Synonyms 90 kDa ribosomal protein S6 kinase 1 | MAP kinase-activated protein kinase 1a | MAPK-activated protein kinase 1a | MAPKAP kinase 1a | MAPKAPK-1a | MAPKAPK1A | RPS6KA1 | RSK-1 | RSK1 | Ribosomal S6 kinase 1 | Ribosomal protein S6 kinase alpha-1 | S6K-alpha-1 | p90-RSK 1 | p90RSK1 | p90S6K
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > camk protein kinase group > camk protein kinase rskb family > camk protein kinase rskb subfamily
  • enzyme > kinase > protein kinase > agc protein kinase group > agc protein kinase rsk family > agc protein kinase rsk subfamily

Target Components

Component Description Relationship Accession
Ribosomal protein S6 kinase alpha-1 SINGLE PROTEIN Q15418

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000117676
Ensembl ENSG00000117676
GO Cellular Component GO:0005654 (nucleoplasm)
GO:0005829 (cytosol)
GO Molecular Function GO:0000287 (magnesium ion binding)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0043027 (caspase inhibitor activity)
GO Biological Process GO:0002755 (MyD88-dependent toll-like receptor signaling pathway)
GO:0002756 (MyD88-independent toll-like receptor signaling pathway)
GO:0006468 (protein phosphorylation)
GO:0007268 (synaptic transmission)
GO:0007411 (axon guidance)
GO:0008063 (Toll signaling pathway)
GO:0034130 (toll-like receptor 1 signaling pathway)
GO:0034134 (toll-like receptor 2 signaling pathway)
GO:0034138 (toll-like receptor 3 signaling pathway)
GO:0034142 (toll-like receptor 4 signaling pathway)
GO:0045087 (innate immune response)
GO:0048011 (nerve growth factor receptor signaling pathway)
GO:0051403 (stress-activated MAPK cascade)
Wikipedia RPS6KA1

Target Cross References - Protein

canSAR Q15418
Human Protein Atlas ENSG00000117676
IntAct Q15418
Guide to Pharmacology 1527 (ribosomal protein S6 kinase, 90kDa, polypeptide 1)
PharmGKB PA34845
Reactome REACT_11061 (Signalling by NGF.)
REACT_13685 (Synaptic Transmission.)
REACT_18266 (Axon guidance.)
REACT_6900 (Signaling in Immune system.)
UniProt A6NGG4 A8K9K7 B2RDY8 B7Z5J0 Q15418 Q5SVM5 Q5SVM8 Q5SVM9 Q96C05 Q9BQK2

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_cat_dom.)
IPR000961 (AGC-kinase_C.)
IPR002290 (Ser/Thr_prot_kinase_dom.)
IPR008271 (Ser/Thr_prot_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR016239 (Ribosomal_S6_kinase_II.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR017442 (Se/Thr_prot_kinase-like_dom.)
IPR017892 (Pkinase_C.)
Pfam PF00069 (Pkinase)
PF00433 (Pkinase_C)

Target Cross References - Structure

PDBe 2WNT 2Z7Q 2Z7R 2Z7S