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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2553
Preferred Name Ribosomal protein S6 kinase alpha 1
Synonyms 90 kDa ribosomal protein S6 kinase 1 | MAP kinase-activated protein kinase 1a | MAPK-activated protein kinase 1a | MAPKAP kinase 1a | MAPKAPK-1a | MAPKAPK1A | RPS6KA1 | RSK-1 | RSK1 | Ribosomal S6 kinase 1 | Ribosomal protein S6 kinase alpha-1 | S6K-alpha-1 | p90-RSK 1 | p90RSK1 | p90S6K
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > camk protein kinase group > camk protein kinase rskb family > camk protein kinase rskb subfamily
  • enzyme > kinase > protein kinase > agc protein kinase group > agc protein kinase rsk family > agc protein kinase rsk subfamily

Target Components

Component Description Relationship Accession
Ribosomal protein S6 kinase alpha-1 SINGLE PROTEIN Q15418

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3832633 Ribosomal protein S6 kinase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000117676 ENSG00000281877
Ensembl ENSG00000117676 ENSG00000281877
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0000287 (magnesium ion binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004712 (protein serine/threonine/tyrosine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0043027 (cysteine-type endopeptidase inhibitor activity involved in apoptotic process)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0006915 (apoptotic process)
GO:0007049 (cell cycle)
GO:0007165 (signal transduction)
GO:0016310 (phosphorylation)
GO:0030307 (positive regulation of cell growth)
GO:0035556 (intracellular signal transduction)
GO:0043066 (negative regulation of apoptotic process)
GO:0043154 (negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0043555 (regulation of translation in response to stress)
GO:0043620 (regulation of DNA-templated transcription in response to stress)
GO:0045597 (positive regulation of cell differentiation)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0072574 (hepatocyte proliferation)
GO:2000491 (positive regulation of hepatic stellate cell activation)
Wikipedia RPS6KA1

Target Cross References - Protein

canSAR Q15418
Human Protein Atlas ENSG00000117676 ENSG00000281877
IntAct Q15418
Guide to Pharmacology 1527
Open Targets ENSG00000117676 ENSG00000281877
PharmGKB PA34845
Pharos Q15418 (Tchem)
Reactome R-HSA-198753 (ERK/MAPK targets.)
R-HSA-199920 (CREB phosphorylation.)
R-HSA-2559582 (Senescence-Associated Secretory Phenotype (SASP).)
R-HSA-437239 (Recycling pathway of L1.)
R-HSA-442742 (CREB phosphorylation through the activation of Ras.)
R-HSA-444257 (RSK activation.)
R-HSA-881907 (Gastrin-CREB signalling pathway via PKC and MAPK.)
UniProt A6NGG4 A8K9K7 B2RDY8 B7Z5J0 E9PRI4 Q15418 Q5SVM5 Q5SVM8 Q5SVM9 Q96C05 Q9BQK2

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR000961 (AGC-kinase_C.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR016239 (Ribosomal_S6_kinase_II.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR017892 (Pkinase_C.)
Pfam PF00069 (Pkinase)
PF00433 (Pkinase_C)

Target Cross References - Structure

PDBe 2WNT 2Z7Q 2Z7R 2Z7S 3RNY 3TEI 4H3P 4NIF 5CSF 5CSI 5CSJ 5CSN 5N7D 5N7F 5N7G 5V61 5V62
CREDO 2WNT 2Z7Q 2Z7R 2Z7S 3RNY 3TEI 4H3P 4NIF 5CSF 5CSI 5CSJ 5CSN 5N7D 5N7F 5N7G 5V61 5V62