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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL255
Preferred Name Adenosine A2b receptor
Synonyms ADORA2B | Adenosine receptor A2b
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > nucleotide-like receptor (family a gpcr) > adenosine receptor

Target Components

Component Description Relationship Accession
Adenosine receptor A2b SINGLE PROTEIN P29275

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2096679 Adenosine receptors; A1 & A2 SELECTIVITY GROUP
CHEMBL2094257 Adenosine A2 receptor PROTEIN FAMILY
CHEMBL2111329 Adenosine receptor PROTEIN FAMILY
CHEMBL2095234 Adenosine receptors; A2b & A3 SELECTIVITY GROUP
CHEMBL2096908 Adenosine receptors; A1 & A2b SELECTIVITY GROUP

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL260933 GS 6201 Adenosine A2b receptor antagonist 1 PubMed
CHEMBL1672627 LAS101057 Adenosine A2b receptor antagonist 1 PubMed
CHEMBL3545204 QAF805 Adenosine A2b receptor antagonist 1 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000170425
Ensembl ENSG00000170425
GO Cellular Component GO:0005887 (integral to plasma membrane)
GO Biological Process GO:0000187 (activation of MAPK activity)
GO:0006968 (cellular defense response)
GO:0007254 (JNK cascade)
GO:0007588 (excretion)
Wikipedia Adenosine_A2B_receptor

Target Cross References - Protein

canSAR P29275
Human Protein Atlas ENSG00000170425
Guide to Pharmacology 20 (A2B)
PharmGKB PA24585
Reactome REACT_14797 (Signaling by GPCR.)
UniProt P29275

Target Cross References - Domain

InterPro IPR000276 (7TM_GPCR_Rhodpsn.)
IPR001435 (Adeno_A2B_rcpt.)
IPR001634 (Adenosn_rcpt.)
IPR017452 (GPCR_Rhodpsn_supfam.)
Pfam PF00001 (7tm_1)