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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2546
Target Type SINGLE PROTEIN
Preferred Name Heme oxygenase 2
Synonyms HMOX2 | HO-2 | HO2 | Heme oxygenase 2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Heme oxygenase 2 SINGLE PROTEIN P30519

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000103415 ENSG00000277424
Ensembl ENSG00000103415 ENSG00000277424
GO Cellular Component GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0035579 (specific granule membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0004392 (heme oxygenase (decyclizing) activity)
GO:0005515 (protein binding)
GO:0016491 (oxidoreductase activity)
GO:0020037 (heme binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0001666 (response to hypoxia)
GO:0006788 (heme oxidation)
GO:0006879 (cellular iron ion homeostasis)
GO:0006979 (response to oxidative stress)
GO:0042167 (heme catabolic process)
GO:0043312 (neutrophil degranulation)
GO:0055072 (iron ion homeostasis)
GO:0055114 (oxidation-reduction process)
Wikipedia HMOX2

Target Cross References - Protein

canSAR P30519
Human Protein Atlas ENSG00000103415 ENSG00000277424
IntAct P30519
Open Targets ENSG00000103415 ENSG00000277424
PharmGKB PA29342
Reactome R-HSA-189483 (Heme degradation.)
R-HSA-6798695 (Neutrophil degranulation.)
R-HSA-917937 (Iron uptake and transport.)
UniProt A8MT35 D3DUD5 I3L430 O60605 P30519

Target Cross References - Domain

InterPro IPR002051 (Haem_Oase.)
IPR016053 (Haem_Oase-like.)
IPR016084 (Haem_Oase-like_multi-hlx.)
IPR018207 (Haem_oxygenase_CS.)
Pfam PF01126 (Heme_oxygenase)

Target Cross References - Structure

PDBe 2Q32 2QPP 2RGZ 4WMH 5UC8 5UC9 5UCA
CREDO 2Q32 2QPP 2RGZ 4WMH 5UC8 5UC9 5UCA
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