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Target Report Card

Target Name and Classification

Target ID CHEMBL2541
Target Type SINGLE PROTEIN
Preferred Name Methylenetetrahydrofolate dehydrogenase
Synonyms C-1-tetrahydrofolate synthase, cytoplasmic | C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed | C1-THF synthase | Formyltetrahydrofolate synthetase | MTHFC | MTHFD | MTHFD1 | Methenyltetrahydrofolate cyclohydrolase | Methylenetetrahydrofolate dehydrogenase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
C-1-tetrahydrofolate synthase, cytoplasmic SINGLE PROTEIN P11586

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000100714
Ensembl ENSG00000100714
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005829 (cytosol)
GO:0016020 (membrane)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003824 (catalytic activity)
GO:0004329 (formate-tetrahydrofolate ligase activity)
GO:0004477 (methenyltetrahydrofolate cyclohydrolase activity)
GO:0004486 (methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity)
GO:0004487 (methylenetetrahydrofolate dehydrogenase (NAD+) activity)
GO:0004488 (methylenetetrahydrofolate dehydrogenase (NADP+) activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016491 (oxidoreductase activity)
GO:0016787 (hydrolase activity)
GO:0016874 (ligase activity)
GO Biological Process GO:0000105 (histidine biosynthetic process)
GO:0001780 (neutrophil homeostasis)
GO:0001843 (neural tube closure)
GO:0006164 (purine nucleotide biosynthetic process)
GO:0006555 (methionine metabolic process)
GO:0006730 (one-carbon metabolic process)
GO:0007507 (heart development)
GO:0008152 (metabolic process)
GO:0008652 (cellular amino acid biosynthetic process)
GO:0009069 (serine family amino acid metabolic process)
GO:0009070 (serine family amino acid biosynthetic process)
GO:0009086 (methionine biosynthetic process)
GO:0009257 (10-formyltetrahydrofolate biosynthetic process)
GO:0009396 (folic acid-containing compound biosynthetic process)
GO:0019346 (transsulfuration)
GO:0035999 (tetrahydrofolate interconversion)
GO:0046655 (folic acid metabolic process)
GO:0048702 (embryonic neurocranium morphogenesis)
GO:0048703 (embryonic viscerocranium morphogenesis)
GO:0055114 (oxidation-reduction process)
GO:0061053 (somite development)
Wikipedia MTHFD1

Target Cross References - Protein

canSAR P11586
CGD Severe combined immunodeficiency
Human Protein Atlas ENSG00000100714
IntAct P11586
Open Targets ENSG00000100714
PharmGKB PA31236
Reactome R-HSA-196757 (Metabolism of folate and pterines.)
UniProt B2R5Y2 G3V2B8 P11586 Q86VC9 Q9BVP5

Target Cross References - Domain

InterPro IPR000559 (Formate_THF_ligase.)
IPR000672 (THF_DH/CycHdrlase.)
IPR016040 (NAD(P)-bd_dom.)
IPR020628 (Formate_THF_ligase_CS.)
IPR020630 (THF_DH/CycHdrlase_cat_dom.)
IPR020631 (THF_DH/CycHdrlase_NAD-bd_dom.)
IPR020867 (THF_DH/CycHdrlase_CS.)
IPR027417 (P-loop_NTPase.)
Pfam PF00763 (THF_DHG_CYH)
PF01268 (FTHFS)
PF02882 (THF_DHG_CYH_C)

Target Cross References - Structure

PDBe 1A4I 1DIA 1DIB 1DIG
CREDO 1A4I 1DIA 1DIB 1DIG
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