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Target Report Card

Target Name and Classification

Target ID CHEMBL2535
Target Type SINGLE PROTEIN
Preferred Name Glucose transporter
Synonyms GLUT-1 | GLUT1 | Glucose transporter type 1, erythrocyte/brain | HepG2 glucose transporter | SLC2A1 | Solute carrier family 2, facilitated glucose transporter member 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > electrochemical transporter > slc superfamily of solute carriers > slc02 family of hexose and sugar alcohol transporters

Target Components

Component Description Relationship Accession
Solute carrier family 2, facilitated glucose transporter member 1 SINGLE PROTEIN P11166

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000117394
Ensembl ENSG00000117394
GO Cellular Component GO:0001939 (female pronucleus)
GO:0000139 (Golgi membrane)
GO:0005887 (integral component of plasma membrane)
GO:0030496 (midbody)
GO:0005829 (cytosol)
GO:0042470 (melanosome)
GO:0016020 (membrane)
GO:0070062 (extracellular exosome)
GO:0005901 (caveola)
GO:0016323 (basolateral plasma membrane)
GO:0030864 (cortical actin cytoskeleton)
GO:0005886 (plasma membrane)
GO:0005911 (cell-cell junction)
GO:0072562 (blood microparticle)
GO Molecular Function GO:0033300 (dehydroascorbic acid transporter activity)
GO:0042910 (xenobiotic transporter activity)
GO:0043621 (protein self-association)
GO:0005351 (sugar:proton symporter activity)
GO:0042802 (identical protein binding)
GO:0005355 (glucose transmembrane transporter activity)
GO:0055056 (D-glucose transmembrane transporter activity)
GO Biological Process GO:0046323 (glucose import)
GO:0044281 (small molecule metabolic process)
GO:0055085 (transmembrane transport)
GO:0006766 (vitamin metabolic process)
GO:0006970 (response to osmotic stress)
GO:0042149 (cellular response to glucose starvation)
GO:0019852 (L-ascorbic acid metabolic process)
GO:0008645 (hexose transport)
GO:0006112 (energy reserve metabolic process)
GO:0006461 (protein complex assembly)
GO:0005975 (carbohydrate metabolic process)
GO:0015758 (glucose transport)
GO:0015992 (proton transport)
GO:0035428 (hexose transmembrane transport)
GO:0050796 (regulation of insulin secretion)
GO:1904659 (glucose transmembrane transport)
GO:0005989 (lactose biosynthetic process)
GO:0006767 (water-soluble vitamin metabolic process)
Wikipedia GLUT1

Target Cross References - Protein

canSAR P11166
CGD GLUT1 deficiency syndrome 1; GLUT1 deficiency syndrome 2
Human Protein Atlas ENSG00000117394
IntAct P11166
Guide to Pharmacology 875 (Glucose transporter 1)
PharmGKB PA35875
UniProt D3DPX0 O75535 Q147X2 A8K9S6 P11166 B2R620

Target Cross References - Domain

InterPro IPR003663 (Sugar/inositol_transpt.)
IPR005829 (Sugar_transporter_CS.)
IPR020846 (MFS_dom.)
IPR002439 (Glu_transpt_1.)
IPR005828 (MFS_sugar_transport_like.)
Pfam PF00083 (Sugar_tr)

Target Cross References - Structure

PDBe 4PYP
CREDO 4PYP
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