ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL2535
Target Type SINGLE PROTEIN
Preferred Name Glucose transporter
Synonyms GLUT-1 | GLUT1 | Glucose transporter type 1, erythrocyte/brain | HepG2 glucose transporter | SLC2A1 | Solute carrier family 2, facilitated glucose transporter member 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > electrochemical transporter > slc superfamily of solute carriers > slc02 family of hexose and sugar alcohol transporters

Target Components

Component Description Relationship Accession
Solute carrier family 2, facilitated glucose transporter member 1 SINGLE PROTEIN P11166

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000117394
Ensembl ENSG00000117394
GO Cellular Component GO:0000139 (Golgi membrane)
GO:0001939 (female pronucleus)
GO:0005622 (intracellular)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0005901 (caveola)
GO:0005911 (cell-cell junction)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016323 (basolateral plasma membrane)
GO:0016324 (apical plasma membrane)
GO:0030496 (midbody)
GO:0030864 (cortical actin cytoskeleton)
GO:0031982 (vesicle)
GO:0042470 (melanosome)
GO:0045121 (membrane raft)
GO:0070062 (extracellular exosome)
GO:0072562 (blood microparticle)
GO Molecular Function GO:0005215 (transporter activity)
GO:0005355 (glucose transmembrane transporter activity)
GO:0005515 (protein binding)
GO:0019900 (kinase binding)
GO:0022857 (transmembrane transporter activity)
GO:0022891 (substrate-specific transmembrane transporter activity)
GO:0033300 (dehydroascorbic acid transporter activity)
GO:0042802 (identical protein binding)
GO:0042910 (xenobiotic transporter activity)
GO:0043621 (protein self-association)
GO:0055056 (D-glucose transmembrane transporter activity)
GO Biological Process GO:0005989 (lactose biosynthetic process)
GO:0006461 (protein complex assembly)
GO:0006810 (transport)
GO:0006970 (response to osmotic stress)
GO:0008643 (carbohydrate transport)
GO:0015758 (glucose transport)
GO:0019852 (L-ascorbic acid metabolic process)
GO:0042149 (cellular response to glucose starvation)
GO:0042908 (xenobiotic transport)
GO:0050796 (regulation of insulin secretion)
GO:0055085 (transmembrane transport)
GO:0070837 (dehydroascorbic acid transport)
GO:1904659 (glucose transmembrane transport)
Wikipedia GLUT1

Target Cross References - Protein

canSAR P11166
CGD GLUT1 deficiency syndrome 1; GLUT1 deficiency syndrome 2
Human Protein Atlas ENSG00000117394
IntAct P11166
Guide to Pharmacology 875
Open Targets ENSG00000117394
PharmGKB PA35875
Reactome R-HSA-196836 (Vitamin C (ascorbate) metabolism.)
R-HSA-422356 (Regulation of insulin secretion.)
R-HSA-428790 (Facilitative Na+-independent glucose transporters.)
R-HSA-5653890 (Lactose synthesis.)
R-HSA-70153 (Glucose transport.)
UniProt A8K9S6 B2R620 D3DPX0 O75535 P11166 Q147X2

Target Cross References - Domain

InterPro IPR002439 (Glu_transpt_1.)
IPR003663 (Sugar/inositol_transpt.)
IPR005828 (MFS_sugar_transport-like.)
IPR005829 (Sugar_transporter_CS.)
IPR020846 (MFS_dom.)
Pfam PF00083 (Sugar_tr)

Target Cross References - Structure

PDBe 4PYP 5EQG 5EQH 5EQI
CREDO 4PYP 5EQG 5EQH 5EQI
spacer
spacer