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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2534
Target Type SINGLE PROTEIN
Preferred Name 3-phosphoinositide dependent protein kinase-1
Synonyms 3-phosphoinositide-dependent protein kinase 1 | PDK1 | PDPK1 | hPDK1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > agc protein kinase group > agc protein kinase pdk1 subfamily

Target Components

Component Description Relationship Accession
3-phosphoinositide-dependent protein kinase 1 SINGLE PROTEIN O15530

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000140992
Ensembl ENSG00000140992
GO Cellular Component GO:0005654 (nucleoplasm)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO Molecular Function GO:0004676 (3-phosphoinositide-dependent protein kinase activity)
GO:0005524 (ATP binding)
GO Biological Process GO:0006469 (negative regulation of protein kinase activity)
GO:0007268 (synaptic transmission)
GO:0008286 (insulin receptor signaling pathway)
GO:0018107 (peptidyl-threonine phosphorylation)
GO:0030036 (actin cytoskeleton organization)
GO:0030168 (platelet activation)
GO:0031295 (T cell costimulation)
GO:0032148 (activation of protein kinase B activity)
GO:0048011 (nerve growth factor receptor signaling pathway)
GO:0048015 (phosphatidylinositol-mediated signaling)
GO:0050852 (T cell receptor signaling pathway)
GO:0090004 (positive regulation of establishment of protein localization in plasma membrane)
Wikipedia Phosphoinositide-dependent_kinase-1

Target Cross References - Protein

canSAR O15530
Human Protein Atlas ENSG00000140992
IntAct O15530
Guide to Pharmacology 1519 (3-phosphoinositide dependent protein kinase 1)
PharmGKB PA33160
Reactome REACT_11061 (Signalling by NGF.)
REACT_13552 (Integrin cell surface interactions.)
REACT_13685 (Synaptic Transmission.)
REACT_14797 (Signaling by GPCR.)
REACT_498 (Signaling by Insulin receptor.)
REACT_604 (Hemostasis.)
REACT_6900 (Signaling in Immune system.)
UniProt O15530 Q6FI20 Q8IV52 Q9BRD5

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_cat_dom.)
IPR002290 (Ser/Thr_prot_kinase_dom.)
IPR008271 (Ser/Thr_prot_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR011993 (PH_type.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR017442 (Se/Thr_prot_kinase-like_dom.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 1H1W 1OKY 1OKZ 1UU3 1UU7 1UU8 1UU9 1UVR 1W1D 1W1G 1W1H 1Z5M 2BIY 2PE0 2PE1 2PE2 2R7B 2VKI 2XCH 2XCK 3H9O 3HRC 3HRF 3ION More...
CREDO 1H1W 1OKY 1OKZ 1UU3 1UU7 1UU8 1UU9 1UVR 1W1D 1W1G 1W1H 1Z5M 2BIY 2PE0 2PE1 2PE2 2R7B 2VKI 2XCH 2XCK 3H9O 3HRC 3HRF 3ION More...
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