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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2527
Target Type SINGLE PROTEIN
Preferred Name Serine/threonine-protein kinase Chk2
Synonyms CDS1 | CHEK2 | CHK2 checkpoint homolog | CHK2 | Cds1 homolog | Checkpoint kinase 2 | Hucds1 | RAD53 | Serine/threonine-protein kinase Chk2 | hCds1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > camk protein kinase group > camk protein kinase rad53 family

Target Components

Component Description Relationship Accession
Serine/threonine-protein kinase Chk2 SINGLE PROTEIN O96017

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL3544936 XL-844 Serine/threonine-protein kinase Chk2 inhibitor 1

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000183765
Ensembl ENSG00000183765
GO Cellular Component GO:0005654 (nucleoplasm)
GO:0005794 (Golgi apparatus)
GO:0016605 (PML body)
GO Molecular Function GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0019901 (protein kinase binding)
GO:0031625 (ubiquitin protein ligase binding)
GO:0042802 (identical protein binding)
GO:0042803 (protein homodimerization activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0000077 (DNA damage checkpoint)
GO:0000086 (G2/M transition of mitotic cell cycle)
GO:0001302 (replicative cell aging)
GO:0006281 (DNA repair)
GO:0006302 (double-strand break repair)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006468 (protein phosphorylation)
GO:0006974 (cellular response to DNA damage stimulus)
GO:0006975 (DNA damage induced protein phosphorylation)
GO:0007049 (cell cycle)
GO:0008630 (DNA damage response, signal transduction resulting in induction of apoptosis)
GO:0008630 (intrinsic apoptotic signaling pathway in response to DNA damage)
GO:0010332 (response to gamma radiation)
GO:0042176 (regulation of protein catabolic process)
GO:0042770 (signal transduction in response to DNA damage)
GO:0044257 (cellular protein catabolic process)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0046777 (protein autophosphorylation)
GO:0050821 (protein stabilization)
GO:0051301 (cell division)
GO:0072428 (signal transduction involved in intra-S DNA damage checkpoint)
GO:0090307 (mitotic spindle assembly)
GO:0090399 (replicative senescence)
Wikipedia CHEK2

Target Cross References - Protein

canSAR O96017
CGD Li-Fraumeni syndrome 2
Human Protein Atlas ENSG00000183765
IntAct O96017
PharmGKB PA404
UniProt A8K3Y9 B7ZBF3 B7ZBF4 B7ZBF5 O96017 Q6QA03 Q6QA04 Q6QA05 Q6QA06 Q6QA07 Q6QA08 Q6QA10 Q6QA11 Q6QA12 Q6QA13 Q9HCQ8 Q9UGF0 Q9UGF1

Target Cross References - Domain

InterPro IPR000253 (FHA_dom.)
IPR000719 (Prot_kinase_cat_dom.)
IPR000719 (Prot_kinase_dom.)
IPR002290 (Ser/Thr_dual-sp_kinase.)
IPR002290 (Ser/Thr_prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR008271 (Ser/Thr_prot_kinase_AS.)
IPR008984 (SMAD_FHA_domain.)
IPR011009 (Kinase-like_dom.)
IPR017442 (Se/Thr_prot_kinase-like_dom.)
IPR020636 (Ca/CaM-dep_Ca-dep_prot_Kinase.)
Pfam PF00069 (Pkinase)
PF00498 (FHA)

Target Cross References - Structure

PDBe 1GXC 2CN5 2CN8 2W0J 2W7X 2WTC 2WTD 2WTI 2WTJ 2XBJ 2XK9 2XM8 2XM9 2YCF 2YCQ 2YCR 2YCS 2YIQ 2YIR 2YIT 3I6U 3I6W 3VA4 4A9R More...
CREDO 1GXC 2CN5 2CN8 2W0J 2W7X 2WTC 2WTD 2WTI 2WTJ 2XBJ 2XK9 2XM8 2XM9 2YCF 2YCQ 2YCR 2YCS 2YIQ 2YIR 2YIT 3I6U 3I6W 3VA4 4A9R More...
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