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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2524
Target Type SINGLE PROTEIN
Preferred Name Alpha-galactosidase A
Synonyms Alpha-D-galactosidase A | Alpha-D-galactoside galactohydrolase | Alpha-galactosidase A | GLA | INN=Agalsidase | Melibiase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Alpha-galactosidase A SINGLE PROTEIN P06280

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000102393
Ensembl ENSG00000102393
GO Cellular Component GO:0005576 (extracellular region)
GO:0005764 (lysosome)
GO:0005794 (Golgi apparatus)
GO Molecular Function GO:0004557 (alpha-galactosidase activity)
GO:0005102 (receptor binding)
GO:0042803 (protein homodimerization activity)
GO:0043169 (cation binding)
GO Biological Process GO:0009311 (oligosaccharide metabolic process)
GO:0016139 (glycoside catabolic process)
GO:0045019 (negative regulation of nitric oxide biosynthetic process)
GO:0046477 (glycosylceramide catabolic process)
GO:0046479 (glycosphingolipid catabolic process)
GO:0051001 (negative regulation of nitric-oxide synthase activity)
Wikipedia Alpha-galactosidase

Target Cross References - Protein

canSAR P06280
CGD Fabry disease; Fabry disease, cardiac variant
Human Protein Atlas ENSG00000102393
PharmGKB PA28707
UniProt P06280

Target Cross References - Domain

InterPro IPR000111 (Glyco_hydro_GHD.)
IPR002241 (Glyco_hydro_27.)
IPR013780 (Glyco_hydro_13_b.)
IPR013785 (Aldolase_TIM.)
IPR017853 (Glycoside_hydrolase_SF.)
Pfam PF02065 (Melibiase)

Target Cross References - Structure

PDBe 1R46 1R47 3GXN 3GXP 3GXT 3HG2 3HG3 3HG4 3HG5 3LX9 3LXA 3LXB 3LXC
CREDO 1R46 1R47 3GXN 3GXP 3GXT 3HG2 3HG3 3HG4 3HG5 3LX9 3LXA 3LXB 3LXC
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