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Target Report Card

Target Name and Classification

Target ID CHEMBL2519
Preferred Name Neutral alpha-glucosidase AB
Synonyms Alpha-glucosidase 2 | G2AN | GANAB | Glucosidase II subunit alpha | KIAA0088 | Neutral alpha-glucosidase AB
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Neutral alpha-glucosidase AB SINGLE PROTEIN Q14697

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000089597
Ensembl ENSG00000089597
GO Cellular Component GO:0005783 (endoplasmic reticulum)
GO:0005788 (endoplasmic reticulum lumen)
GO:0005794 (Golgi apparatus)
GO:0016020 (membrane)
GO:0017177 (glucosidase II complex)
GO:0031012 (extracellular matrix)
GO:0042470 (melanosome)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0003824 (catalytic activity)
GO:0004553 (hydrolase activity, hydrolyzing O-glycosyl compounds)
GO:0016787 (hydrolase activity)
GO:0016798 (hydrolase activity, acting on glycosyl bonds)
GO:0030246 (carbohydrate binding)
GO:0033919 (glucan 1,3-alpha-glucosidase activity)
GO:0044822 (poly(A) RNA binding)
GO Biological Process GO:0005975 (carbohydrate metabolic process)
GO:0006457 (protein folding)
GO:0008152 (metabolic process)
Wikipedia GANAB

Target Cross References - Protein

canSAR Q14697
Human Protein Atlas ENSG00000089597
IntAct Q14697
Open Targets ENSG00000089597
PharmGKB PA28551
Reactome R-HSA-532668 (N-glycan trimming in the ER and Calnexin/Calreticulin cycle.)
R-HSA-901042 (Calnexin/calreticulin cycle.)
UniProt A6NC20 Q14697 Q8WTS9 Q9P0X0

Target Cross References - Domain

InterPro IPR000322 (Glyco_hydro_31.)
IPR011013 (Gal_mutarotase_SF_dom.)
IPR017853 (Glycoside_hydrolase_SF.)
IPR025887 (Glyco_hydro_31_N_dom.)
IPR030458 (Glyco_hydro_31_AS.)
IPR030459 (Glyco_hydro_31_CS.)
Pfam PF01055 (Glyco_hydro_31)
PF13802 (Gal_mutarotas_2)