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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2508
Target Type SINGLE PROTEIN
Preferred Name Cyclin-dependent kinase 6
Synonyms CDK6 | CDKN6 | Cell division protein kinase 6 | Cyclin-dependent kinase 6 | Serine/threonine-protein kinase PLSTIRE
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > cmgc protein kinase group

Target Components

Component Description Relationship Accession
Cyclin-dependent kinase 6 SINGLE PROTEIN Q00534

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111455 CDK6/cyclin D1 PROTEIN COMPLEX
CHEMBL3301386 CDK6/cyclin D2 PROTEIN COMPLEX
CHEMBL3559691 Cyclin-dependent kinase PROTEIN FAMILY
CHEMBL2111448 CDK6/cyclin D3 PROTEIN COMPLEX

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL3545110 Ribociclib Cyclin-dependent kinase 6 inhibitor 4 Other PubMed
CHEMBL3707266 RIBOCICLIB SUCCINATE Cyclin-dependent kinase 6 inhibitor 4 Other PubMed
CHEMBL428690 ALVOCIDIB Cyclin-dependent kinase 6 inhibitor 3 PubMed PubMed
CHEMBL3301610 ABEMACICLIB Cyclin-dependent kinase 6 inhibitor 3 PubMed
CHEMBL574737 (7S)-HYDROXYL-STAUROSPORINE Cyclin-dependent kinase 6 inhibitor 2 Other PubMed PubMed
CHEMBL3544940 G1T28-1 Cyclin-dependent kinase 6 inhibitor 1

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000105810
Ensembl ENSG00000105810
GO Cellular Component GO:0000307 (cyclin-dependent protein kinase holoenzyme complex)
GO:0001726 (ruffle)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005813 (centrosome)
GO:0005815 (microtubule organizing center)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0042995 (cell projection)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004693 (cyclin-dependent protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0030332 (cyclin binding)
GO Biological Process GO:0000082 (G1/S transition of mitotic cell cycle)
GO:0001954 (positive regulation of cell-matrix adhesion)
GO:0002244 (hematopoietic progenitor cell differentiation)
GO:0003323 (type B pancreatic cell development)
GO:0006468 (protein phosphorylation)
GO:0007049 (cell cycle)
GO:0007050 (cell cycle arrest)
GO:0007219 (Notch signaling pathway)
GO:0008285 (negative regulation of cell proliferation)
GO:0009615 (response to virus)
GO:0010468 (regulation of gene expression)
GO:0010628 (positive regulation of gene expression)
GO:0014002 (astrocyte development)
GO:0016310 (phosphorylation)
GO:0021542 (dentate gyrus development)
GO:0021670 (lateral ventricle development)
GO:0030097 (hemopoiesis)
GO:0030154 (cell differentiation)
GO:0033077 (T cell differentiation in thymus)
GO:0042063 (gliogenesis)
GO:0042127 (regulation of cell proliferation)
GO:0043697 (cell dedifferentiation)
GO:0045596 (negative regulation of cell differentiation)
GO:0045638 (negative regulation of myeloid cell differentiation)
GO:0045646 (regulation of erythrocyte differentiation)
GO:0045668 (negative regulation of osteoblast differentiation)
GO:0045786 (negative regulation of cell cycle)
GO:0048146 (positive regulation of fibroblast proliferation)
GO:0048699 (generation of neurons)
GO:0050680 (negative regulation of epithelial cell proliferation)
GO:0051301 (cell division)
GO:0060218 (hematopoietic stem cell differentiation)
GO:2000145 (regulation of cell motility)
GO:2000773 (negative regulation of cellular senescence)
Wikipedia Cyclin-dependent_kinase_6

Target Cross References - Protein

canSAR Q00534
Human Protein Atlas ENSG00000105810
IntAct Q00534
Guide to Pharmacology 1978
Open Targets ENSG00000105810
PharmGKB PA103
Pharos Q00534 (Tclin)
Reactome R-HSA-2559580 (Oxidative Stress Induced Senescence.)
R-HSA-2559582 (Senescence-Associated Secretory Phenotype (SASP).)
R-HSA-2559585 (Oncogene Induced Senescence.)
R-HSA-69231 (Cyclin D associated events in G1.)
UniProt A4D1G0 Q00534

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR028788 (CDK6.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 1BI7 1BI8 1BLX 1G3N 1JOW 1XO2 2EUF 2F2C 3NUP 3NUX 4AUA 4EZ5 4TTH 5L2I 5L2S 5L2T
CREDO 1BI7 1BI8 1BLX 1G3N 1JOW 1XO2 2EUF 2F2C 3NUP 3NUX 4AUA 4EZ5 4TTH 5L2I 5L2S 5L2T
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