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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2508
Target Type SINGLE PROTEIN
Preferred Name Cyclin-dependent kinase 6
Synonyms CDK6 | CDKN6 | Cell division protein kinase 6 | Cyclin-dependent kinase 6 | Serine/threonine-protein kinase PLSTIRE
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > cmgc protein kinase group

Target Components

Component Description Relationship Accession
Cyclin-dependent kinase 6 SINGLE PROTEIN Q00534

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3301386 CDK6/cyclin D2 PROTEIN COMPLEX
CHEMBL2111448 CDK6/cyclin D3 PROTEIN COMPLEX
CHEMBL2111455 CDK6/cyclin D1 PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000105810
Ensembl ENSG00000105810
GO Cellular Component GO:0000307 (cyclin-dependent protein kinase holoenzyme complex)
GO:0001726 (ruffle)
GO:0005634 (nucleus)
GO:0005829 (cytosol)
GO Molecular Function GO:0004693 (cyclin-dependent protein kinase activity)
GO:0005524 (ATP binding)
GO:0030332 (cyclin binding)
GO Biological Process GO:0000080 (G1 phase of mitotic cell cycle)
GO:0001954 (positive regulation of cell-matrix adhesion)
GO:0006468 (protein phosphorylation)
GO:0009615 (response to virus)
GO:0010468 (regulation of gene expression)
GO:0042063 (gliogenesis)
GO:0043697 (cell dedifferentiation)
GO:0045646 (regulation of erythrocyte differentiation)
GO:0045668 (negative regulation of osteoblast differentiation)
GO:0045786 (negative regulation of cell cycle)
GO:0048146 (positive regulation of fibroblast proliferation)
GO:0050680 (negative regulation of epithelial cell proliferation)
GO:0051301 (cell division)
Wikipedia Cyclin-dependent_kinase_6

Target Cross References - Protein

canSAR Q00534
Human Protein Atlas ENSG00000105810
IntAct Q00534
Guide to Pharmacology 1978 (cyclin-dependent kinase 6)
PharmGKB PA103
Reactome REACT_152 (Cell Cycle, Mitotic.)
UniProt Q00534

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_cat_dom.)
IPR002290 (Ser/Thr_prot_kinase_dom.)
IPR008271 (Ser/Thr_prot_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR017442 (Se/Thr_prot_kinase-like_dom.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 1BI7 1BI8 1BLX 1G3N 1JOW 1XO2 2EUF 2F2C 3NUP 3NUX
CREDO 1BI7 1BI8 1BLX 1G3N 1JOW 1XO2 2EUF 2F2C 3NUP 3NUX
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