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Target Report Card

Target Name and Classification

Target ID CHEMBL2505
Target Type SINGLE PROTEIN
Preferred Name Protein phosphatase 2A regulatory subunit B'
Synonyms PP2A, subunit B', PR53 isoform | PPP2R4 | PTPA | PTPA | Phosphotyrosyl phosphatase activator | Serine/threonine-protein phosphatase 2A activator | Serine/threonine-protein phosphatase 2A regulatory subunit 4 | Serine/threonine-protein phosphatase 2A regulatory subunit B'
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > phosphatase > protein phosphatase > protein phosphatase regulatory subunit

Target Components

Component Description Relationship Accession
Serine/threonine-protein phosphatase 2A activator SINGLE PROTEIN Q15257

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000119383
Ensembl ENSG00000119383
GO Cellular Component GO:0000159 (protein phosphatase type 2A complex)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0034704 (calcium channel complex)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003755 (peptidyl-prolyl cis-trans isomerase activity)
GO:0005102 (receptor binding)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008160 (protein tyrosine phosphatase activator activity)
GO:0008601 (protein phosphatase type 2A regulator activity)
GO:0016853 (isomerase activity)
GO:0016887 (ATPase activity)
GO:0019211 (phosphatase activator activity)
GO:0042803 (protein homodimerization activity)
GO:0046982 (protein heterodimerization activity)
GO:0051721 (protein phosphatase 2A binding)
GO Biological Process GO:0000413 (protein peptidyl-prolyl isomerization)
GO:0030472 (mitotic spindle organization in nucleus)
GO:0032515 (negative regulation of phosphoprotein phosphatase activity)
GO:0032516 (positive regulation of phosphoprotein phosphatase activity)
GO:0034047 (regulation of protein phosphatase type 2A activity)
GO:0035307 (positive regulation of protein dephosphorylation)
GO:0035308 (negative regulation of protein dephosphorylation)
GO:0043065 (positive regulation of apoptotic process)
GO:0043666 (regulation of phosphoprotein phosphatase activity)
Wikipedia PPP2R4

Target Cross References - Protein

canSAR Q15257
Human Protein Atlas ENSG00000119383
IntAct Q15257
Open Targets ENSG00000119383
PharmGKB PA33671
UniProt A2A347 A9IZU4 B4DXM4 Q15257 Q15258 Q53GZ3 Q5TZQ2 Q9BUK1 Q9NNZ7 Q9NNZ8 Q9NNZ9

Target Cross References - Domain

InterPro IPR004327 (Phstyr_phstse_ac.)
Pfam PF03095 (PTPA)

Target Cross References - Structure

PDBe 2G62 2HV6 2HV7 2IXM 4LAC 4NY3
CREDO 2G62 2HV6 2HV7 2IXM 4LAC 4NY3
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